Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants.

Journal of Zhejiang University. Science. B
Dan-li FuLi Liu

Abstract

The purpose of this study was to analyze the effect of strontium-substituted hydroxyapatite (Sr-HA) on bone osseointegration of the implants using fluorescence microscopy. We allocated 20 implants to two groups: Sr-HA group and HA group. Electrochemically deposited HA and Sr-HA coatings were applied onto the implants separately. All the implants were inserted into femur bone of rabbits. Oxytetracycline hydrochloride, alizarin-complexon, and calcein green were respectively administered 7, 28, and 46 d after the implantation. After eight weeks, femurs were retrieved and prepared for the fluorescence microscopy observation. We analyzed the bone mineral apposition rates (MARs), bone area ratios (BARs), and bone to implant contact (BIC) of the two groups. Fluorescence microscopic observation showed that all groups exhibited extensive early peri-implant bone formation. The MAR of the Sr-HA group was greater than that for pure HA from 7 to 28 d after implantation, but no significant difference was found at later stage. And the BIC showed difference at 7 and 28 d compared with pure HA. We concluded that Sr-HA coating can improve the bone osseointegration of the implant in the early stage compared with the HA coating.

References

Jul 1, 1997·Journal of Biomedical Materials Research·T HanawaK Asaoka
Jul 23, 1999·International Journal of Oral and Maxillofacial Surgery·B FribergU Lekholm
Feb 13, 2001·Clinical Oral Implants Research·S Szmukler-MonclerJ H Dubruille
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·N PatelP A Revell
Jun 25, 2005·Biomaterials·Young-Taeg SulTomas Albrektsson
Oct 18, 2007·Journal of Biomedical Materials Research. Part a·Jin-Woo ParkHyun-Ju Chung
Feb 14, 2008·Journal of Materials Science. Materials in Medicine·Weichang XueSusmita Bose
Feb 10, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Guo-li YangShi-fang Zhao
Sep 4, 2009·Journal of Materials Science. Materials in Medicine·Guo X NiWilliam W Lu
Dec 31, 2009·Acta Biomaterialia·E BoaniniA Bigi
Sep 10, 2010·Acta Biomaterialia·Weibin ZhangWenhai Huang
Mar 3, 2011·Journal of Materials Science. Materials in Medicine·Guo-Xin NiWilliam W Lu
Jun 30, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mangal RoySusmita Bose
Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Fan YangGuo-li Yang

❮ Previous
Next ❯

Citations

Sep 15, 2014·Acta Biomaterialia·Laura KyllönenDavid Eglin
Oct 12, 2013·The American Journal of Pathology·Sandra PaciosDana T Graves
Sep 24, 2013·Journal of Dental Research·H S AlghamdiJ A Jansen
Feb 13, 2019·Nanomaterials·Ionela Andreea NeacsuEcaterina Andronescu
Feb 28, 2019·Clinical Orthopaedics and Related Research·Irene Gallardo-CaleroRoberto Vélez
Jun 10, 2019·Clinical Hemorheology and Microcirculation·Rebecca RotheJens Pietzsch
Dec 9, 2019·ACS Biomaterials Science & Engineering·Thuy-Duong Thi NguyenTae-Sung Bae

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.