Fluorescence resonance energy transfer (FRET) based nanoparticles composed of AIE luminogens and NIR dyes with enhanced three-photon near-infrared emission for in vivo brain angiography

Nanoscale
Wen LiuSailing He

Abstract

Near-infrared (NIR) fluorescence is very important for high-contrast biological imaging of high-scattering tissues such as brain tissue. Unfortunately, commercial NIR dyes are excited usually by visible light, and their multi-photon absorption (MPA) cross-sections are small. Here, we design new co-encapsulated NIR nanoparticles (NPs) with a large three-photon (3PA) absorption cross-section. A form of aggregation-induced emission (AIE) luminogen (AIEgen), 2,3-bis(4'-(diphenylamino)-[1,1'-biphenyl]-4-yl) fumaronitrile (TPATCN), is introduced as the donor, and a form of NIR dye, silicon 2,3-naphthalocyanine bis-(trihexylsilyloxide) (NIR775), is adopted as the acceptor. Under the excitation of a 1550 nm fs laser, TPATCN-NIR775 NPs demonstrated a bright three-photon fluorescence centered at 785 nm. The energy transfer efficiency of the TPATCN-NIR775 NPs was calculated to be as high as 90%, which could be attributed to the good spectral overlap between the emission of TPATCN and the absorption of NIR775. By injection with TPATCN-NIR775 NPs, a vivid 3D reconstruction of mouse brain vasculature was obtained with even small blood vessels clearly visualized. The design strategy used for the co-encapsulated AIE-NIR NPs would be helpful in...Continue Reading

References

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Citations

Oct 16, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Evgeniya A SafonovaAslan Yu Tsivadze
Aug 10, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lingchen MengWenjing Tian
Oct 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenkun HanWenjing Tian
Jan 30, 2021·Scientific Reports·Shih-Wen ChenThomas Chung-Kuang Yang
Apr 8, 2021·Topics in Current Chemistry·Lei DongQing-Zheng Yang
May 21, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Changting CaiQiong Zhang
Aug 22, 2021·Advanced Healthcare Materials·Yuqing WangXing-Jie Liang
Nov 19, 2021·The Journal of Physical Chemistry. a·Rongji ZhuJiawei Xu

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Methods Mentioned

BETA
fluorescence
FRET
dynamic light scattering
nanoprecipitation
enzyme-linked immunosorbent assay
fluorescence imaging
transmission electron microscopy

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