Fluorescent 2D WS2 Nanosheets Bearing Chemical Affinity Elements for the Recognition of Glycated Hemoglobin

Advanced Healthcare Materials
Jin-Kyoung YangJong-Ho Kim

Abstract

It is required to exfoliate and functionalize 2D transition metal dichalcogenides (TMDs) in an aqueous solution for biological and medical applications. Herein, the approach for the simultaneous exfoliation and functionalization of 2D WS2 nanosheets using boronic acid-modified poly(vinyl alcohol) (B-PVA) in an aqueous solution is reported, and the B-PVA-functionalized WS2 nanosheets (B-PVA-WS2 ) are exploited as a fluorescent biosensor for the detection of glycated hemoglobin, HbA1c. The synthetic B-PVA polymer facilitates the exfoliation and functionalization of WS2 nanosheets from the bulk counterpart in the aqueous solution via a pulsed sonication process, resulting in fluorescent B-PVA-WS2 nanohybrids with a specific recognition of HbA1c. The fluorescence of the B-PVA-WS2 is quenched in the presence of HbA1c, whereas PVA-functionalized WS2 (PVA-WS2 ), not bearing boronic acid as a recognition moiety, shows no fluorescence changes upon the addition of the target. The B-PVA-WS2 is able to selectively detect HbA1c at the concentration as low as 3.3 × 10-8 m based on its specific fluorescence quenching.

References

Mar 21, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·C M BennettS C Dharmage
Jan 26, 2010·Analytical Chemistry·Manikantan Syamala KiranMitsuru Ishikawa
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Feb 5, 2011·Science·Jonathan N ColemanValeria Nicolosi
Jul 29, 2011·Advanced Materials·Ronan J SmithJonathan N Coleman
Feb 14, 2012·Analytical Chemistry·Ishan BarmanMichael S Feld
Nov 8, 2012·Nature Nanotechnology·Qing Hua WangMichael S Strano
Mar 21, 2013·Nature Chemistry·Manish ChhowallaHua Zhang
Nov 10, 2013·Annals of Laboratory Medicine·Cas Weykamp
Mar 13, 2014·Analytical Chemistry·Yunxia YuanZhihong Liu
Dec 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shu Hwang AngSook Mei Khor
May 6, 2015·Journal of the American Chemical Society·Guijian GuanMing-Yong Han
Jan 7, 2016·ACS Applied Materials & Interfaces·Gyeong Sook BangSung-Yool Choi

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Citations

Jul 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinping ShiCan Yang Zhang
Apr 2, 2020·International Journal of Biological Macromolecules·Pradakshina SharmaJagriti Narang

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