PMID: 20098021Jan 26, 2010Paper

Fluorescent in situ hybridization 1p/19q deletion/imbalance analysis of low-grade and atypical meningiomas

Neurologia Medico-chirurgica
Toru NagasakaSuguru Inao

Abstract

The chromosomal 1p/19q state was analyzed in 16 low-grade meningiomas and 7 atypical meningiomas using fluorescent in situ hybridization (FISH) analysis. Chromosome 1p aberrations were observed in all atypical meningiomas, but in only one low-grade meningioma. Atypical meningiomas showed 19q deletion or imbalance, suggesting chromosomal instability of 19q. A small group of low-grade meningioma showed 19q aberrations. FISH 1p/19q deletion/imbalance analysis is a sensitive method for detecting chromosome aberrations of meningiomas and provides useful information for grading of meningiomas. Patients with low-grade meningioma with chromosomal instability of 1p/19q should be followed up carefully. Assessment of the chromosomal state by FISH might be of crucial importance in the clinical management of meningiomas.

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Dec 21, 2007·Brain Tumor Pathology·Toru NagasakaSuguru Inao

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Citations

Jan 14, 2011·Clinical Neurology and Neurosurgery·George A AlexiouAthanasios P Kyritsis
May 14, 2016·British Journal of Neurosurgery·Recep BasaranIlhan Elmaci
Jul 14, 2016·Journal of Neuro-oncology·Irena Srebotnik-Kirbiš, Clara Limbäck-Stokin

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