During the last few years, the preparation of novel fluorescent probes for the selective detection of chemical species inside mitochondria has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article focuses on the recent advances in the design principles and recognition mechanisms of these kinds of fluorescent probes. In addition, their applications for the detection of reactive oxygen species (ROS), nitric oxide, reactive sulfur species (RSS), thioredoxin (Trx), metal ions, anions, etc. in the mitochondrion is discussed as well.
Pyronin G as a fluorescent probe for quantitative determination of the membrane potential of mitochondria
The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation
Chemical mechanism of ATP synthase. Magnesium plays a pivotal role in formation of the transition state where ATP is synthesized from ADP and inorganic phosphate.
A novel fluorescent probe diphenyl-1-pyrenylphosphine to follow lipid peroxidation in cell membranes
C11-BODIPY(581/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology
Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69
Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species.
Emission ratiometric imaging of intracellular zinc: design of a benzoxazole fluorescent sensor and its application in two-photon microscopy
Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe
Third-generation superoxide anion sensor based on superoxide dismutase directly immobilized by sol-gel thin film on gold electrode
Mass spectrometric characterization of the oxidation of the fluorescent lipid peroxidation reporter molecule C11-BODIPY(581/591)
Synthesis and structural characterisation of the first bis(bora)calixarene: a selective, bidentate, fluorescent fluoride sensor
Design and synthesis of highly sensitive and selective fluorescein-derived magnesium fluorescent probes and application to intracellular 3D Mg2+ imaging
Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs
Strong red fluorescent probes suitable for detecting hydrogen peroxide generated by mice peritoneal macrophages
First fluorescent sensor for fluoride based on 2-ureido-4[1H]-pyrimidinone quadruple hydrogen-bonded AADD supramolecular assembly
Development of a ratiometric fluorescent zinc ion probe in near-infrared region, based on tricarbocyanine chromophore
Fluorescence turn on of coumarin derivatives by metal cations: a new signaling mechanism based on C=N isomerization
Synthesis, Structure, Properties, and Bioimaging of a Fluorescent Nitrogen-Linked Bisbenzothiadiazole
Novel Fluorescein-Based Fluorescent Probe for Detecting H2 S and Its Real Applications in Blood Plasma and Biological Imaging
Sterically Protected N2 O-Type Benzopyrromethene Boron Complexes from Boronic Acids with Intense Red/Near-Infrared Fluorescence
Design of anion-selective PET probes based on azacryptands: the effect of pH on binding and fluorescence properties
Ratiometric Fluorescent Probe for Lysosomal pH Measurement and Imaging in Living Cells Using Single-Wavelength Excitation
Oxidative Intramolecular 1,2-Amino-Oxygenation of Alkynes under AuI /AuIII Catalysis: Discovery of a Pyridinium-Oxazole Dyad as an Ionic Fluorophore
A mitochondria-targeted fluorescence probe for ratiometric detection of endogenous hypochlorite in the living cells
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
A fast response fluorescence probe specific for hypochlorous acid detection and its applications in bioimaging
Organelle-specific bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics
A novel porphyrin-based near-infrared fluorescent probe for hypochlorite detection and its application in vitro and in vivo
A Multifunctional Chemical Probe for the Measurement of Local Micropolarity and Microviscosity in Mitochondria
A cationic organoiridium(iii) complex-based AIEgen for selective light-up detection of rRNA and nucleolar staining
A new mitochondria-targeted ratiometric fluorescent probe based on diketopyrrolopyrrole for imaging endogenous HOCl in living cells
A two-photon ratiometric fluorescent probe for highly selective sensing of mitochondrial cysteine in live cells
Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes
Construction of a fluorescent probe for selectively detecting singlet oxygen with a high sensitivity and large concentration range based on a two-step cascade sensing reaction
Tracing the molecular dynamics of living mitochondria under phototherapy via surface-enhanced Raman scattering spectroscopy
An HBT-Based Near-Infrared Fluorescent Probe for Colorimetric and Ratiometric Detection of Bisulfite and its Application in Living Cells
A NIR-emitting cyanine with large Stokes shifts for live cell imaging: large impact of the phenol group on emission
Ultrafast labeling and high-fidelity imaging of mitochondria in cancer cells using an aggregation-enhanced emission fluorescent probe
Turn-on fluorescence in a pyridine-decorated tetraphenylethylene: the cooperative effect of coordination-driven rigidification and silver ion induced aggregation
A new strategy to improve the water solubility of an organic fluorescent probe using silicon nanodots and fabricate two-photon SiND-ANPA-N3 for visualizing hydrogen sulfide in living cells and onion tissues.
Recent progress on the organic and metal complex-based fluorescent probes for monitoring nitric oxide in living biological systems
Pyridinium-substituted tetraphenylethylene salt-based photosensitizers by varying counter anions: a highly efficient photodynamic therapy for cancer cell ablation and bacterial inactivation.
Two- and three-photon excitable quaternized imidazo[1,2-a ]pyridines as mitochondrial imaging and potent cancer therapy agents
Simple synthesis of multifunctional photosensitizers for mitochondrial and bacterial imaging and photodynamic anticancer and antibacterial therapy
Dual-channel fluorescence diagnosis of cancer cells/tissues assisted by OATP transporters and cysteine/glutathione
Mitochondria targeting and near-infrared fluorescence imaging of a novel heptamethine cyanine anticancer agent
A novel off-on fluorescent probe for sensitive imaging of mitochondria-specific nitroreductase activity in living tumor cells
A three-dimensional (time, wavelength and intensity) functioning fluorescent probe for the selective recognition/discrimination of Cu2+ , Hg2+ , Fe3+ and F- ions
Targetable N-annulated perylene-based colorimetric and ratiometric near-infrared fluorescent probes for the selective detection of hydrogen sulfide in mitochondria, lysosomes, and serum
Horseradish Peroxidase-Encapsulated Hollow Silica Nanospheres for Intracellular Sensing of Reactive Oxygen Species
Visualization of oxidative injury in the mouse kidney using selective superoxide anion fluorescent probes
Development of a mitochondria targetable ratiometric time-gated luminescence probe for biothiols based on lanthanide complexes
A mitochondria-targeting time-gated luminescence probe for hypochlorous acid based on a europium complex
A Disassembly Strategy for Imaging Endogenous Pyrophosphate in Mitochondria by Using an Fe(III) -salen Complex
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