PMID: 8603928Nov 1, 1995Paper

Fluoride accumulation and toxicity in laboratory populations of wild small mammals and white mice

Journal of Applied Toxicology : JAT
I BoultonM Johnson

Abstract

A laboratory experiment was conducted to compare the toxicological response and metabolism of inorganic fluoride by three species of wild mammals and laboratory white mice (Mus musculus L.). The experimental populations of the wild species--the short-tailed field vole (Microtus agrestis L.), the bank vole (Clethrionomys glareolus L.) and the the wood mouse (Apodemus sylvaticus L.)--were laboratory reared from wild stock, and all test animals were exposed to 0, 40 or 80 microgram F per ml in their drinking water for up to 84 days. The 40 and 80 microgram F per ml treatments induced premature mortalities in M. agrestis and C. glareolus only. Differential intakes, absorption and retention of fluoride were evident between M. musculus and M. agrestis, the two species subject to cage studies of fluoride metabolism budgets. Interspecific variation in accumulation of fluoride with time was also evident between all four species as regards the femur, molars and incisors. Severe dental lesions were apparent in species surviving the 80 microgram ml(-1) treatment for 84 days. Overall, however, there were few clear differences in inherent species sensitivity to fluoride, the interspecific variation in metabolism and accumulation rates being ...Continue Reading

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Jan 1, 1994·Environmental Pollution·I C BoultonM S Johnson

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Citations

Dec 8, 2011·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·N I Agalakova, G P Gusev
Dec 4, 2009·Neurotoxicity Research·Marcela PereiraRoberto Andreatini
Nov 16, 2007·European Journal of Pharmacology·Lea R ChiocaRoberto Andreatini
Jun 29, 2011·Biochemical and Biophysical Research Communications·Shiyong YangBo Han
Aug 11, 2011·PloS One·Trine DalkvistChris J Topping
Dec 19, 2016·Anatomical Science International·Zulhaini Sartika A PulunganGinus Partadiredja
Dec 5, 2019·Biological Trace Element Research·Olga V NadeiNatalia I Agalakova

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