Fluoride curcumin derivatives: new mitochondrial uncoupling agents

FEBS Letters
Heidi LigeretDidier Morin

Abstract

The mitochondrial effects of two fluoride curcumin derivatives were studied. They induced the collapse of mitochondrial membrane potential (DeltaPsi), increased mitochondrial respiration, and decreased O(2)*- production and promoted Ca(2+) release. These effects were reversed by the recoupling agent 6-Ketocholestanol, but not by cyclosporin A, an inhibitor of the permeability transition pore (PTP), suggesting that these compounds act as uncoupling agents. This idea was reinforced by the analysis of the physico-chemical properties of the compounds indicating, that they are mainly in the anionic form in the mitochondrial membrane. Moreover, they are able to induce PTP opening by promoting the oxidation of thiol groups and the release of cytochrome c, making these two molecules potential candidates for induction of apoptosis.

References

Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Jan 1, 1997·Immunology Today·G KroemerS A Susin
May 9, 1997·The Journal of Biological Chemistry·L ScorranoP Bernardi
Jun 1, 1997·Bioscience Reports·A A Starkov
Aug 28, 1998·Science·D R Green, J C Reed
Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·A AvdeefK Y Tam
Jul 6, 2000·Journal of the National Cancer Institute·P CostantiniG Kroemer
Apr 27, 2001·FEBS Letters·A J KowaltowskiA E Vercesi
May 30, 2001·Advanced Drug Delivery Reviews·D MorinJ Tillement
Aug 14, 2001·Memórias do Instituto Oswaldo Cruz·C C Araújo, L L Leon
Feb 28, 2002·Journal of Bioenergetics and Biomembranes·Dalia M KopustinskieneAdolfas Toleikis
Aug 31, 2002·Chemistry : a European Journal·Géraldine BouchardHubert H Girault
Mar 17, 2004·Free Radical Biology & Medicine·Heidi LigeretDidier Morin

❮ Previous
Next ❯

Citations

May 10, 2005·Bioorganic & Medicinal Chemistry Letters·Sabari DuttaChris Newton
Apr 28, 2005·Free Radical Biology & Medicine·Satyendra MishraKrishna Misra
Sep 5, 2007·Assay and Drug Development Technologies·Biji T KurienR Hal Scofield
May 3, 2012·International Journal of Cell Biology·Luke R K HughsonJulian J Lum
Apr 29, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Shuai DongKui Wang
Sep 9, 2008·Biochemical Pharmacology·Preetha AnandBharat B Aggarwal
Sep 1, 2009·Biochemical and Biophysical Research Communications·Han Wern LimKim Ping Wong
Jul 5, 2005·Bioorganic & Medicinal Chemistry Letters·Ho Bum WooChan Mug Ahn
Oct 19, 2017·International Journal of Molecular Medicine·Wenjuan TangYan Bi
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla I NietoJosé Luis Lavandera
Mar 31, 2021·Molecular Metabolism·Riya ShresthaFrances L Byrne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis