Abstract
The mitochondrial effects of two fluoride curcumin derivatives were studied. They induced the collapse of mitochondrial membrane potential (DeltaPsi), increased mitochondrial respiration, and decreased O(2)*- production and promoted Ca(2+) release. These effects were reversed by the recoupling agent 6-Ketocholestanol, but not by cyclosporin A, an inhibitor of the permeability transition pore (PTP), suggesting that these compounds act as uncoupling agents. This idea was reinforced by the analysis of the physico-chemical properties of the compounds indicating, that they are mainly in the anionic form in the mitochondrial membrane. Moreover, they are able to induce PTP opening by promoting the oxidation of thiol groups and the release of cytochrome c, making these two molecules potential candidates for induction of apoptosis.
References
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Dec 5, 1994·FEBS Letters·A A StarkovV P Skulachev
Feb 1, 1993·Journal of Pharmaceutical Sciences·A Avdeef
May 1, 1996·Quarterly Reviews of Biophysics·V P Skulachev
Nov 15, 1996·Biochimica Et Biophysica Acta·M L KuoJ K Lin
Jan 1, 1997·Immunology Today·G KroemerS A Susin
Jan 16, 1997·Biochimica Et Biophysica Acta·A A StarkovV P Skulachev
May 9, 1997·The Journal of Biological Chemistry·L ScorranoP Bernardi
Aug 1, 1997·British Journal of Pharmacology·A ElimadiJ P Tillement
Jun 1, 1997·Bioscience Reports·A A Starkov
Nov 22, 1997·FEBS Letters·S S KorshunovA A Starkov
Jul 3, 1998·European Journal of Pharmacology·A ElimadiD Morin
Aug 26, 1998·Cancer Letters·A SimonC Delage
Aug 28, 1998·Science·D R Green, J C Reed
Oct 3, 1999·Physiological Reviews·P Bernardi
Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·A AvdeefK Y Tam
Apr 28, 2000·Carcinogenesis·N N MahmoudM M Bertagnolli
Jul 6, 2000·Journal of the National Cancer Institute·P CostantiniG Kroemer
Aug 5, 2000·Biochimica Et Biophysica Acta·V N SamartsevV P Skulachev
Apr 27, 2001·FEBS Letters·A J KowaltowskiA E Vercesi
Apr 27, 2001·FEBS Letters·D MorinJ P Tillement
May 30, 2001·Advanced Drug Delivery Reviews·D MorinJ Tillement
Aug 14, 2001·Memórias do Instituto Oswaldo Cruz·C C Araújo, L L Leon
Feb 21, 2002·Biochemical Pharmacology·Oliver J StoetzerVolkmar Nuessler
Feb 28, 2002·Journal of Bioenergetics and Biomembranes·Dalia M KopustinskieneAdolfas Toleikis
Aug 31, 2002·Chemistry : a European Journal·Géraldine BouchardHubert H Girault
Mar 17, 2004·Free Radical Biology & Medicine·Heidi LigeretDidier Morin
Citations
May 10, 2005·Bioorganic & Medicinal Chemistry Letters·Sabari DuttaChris Newton
Apr 28, 2005·Free Radical Biology & Medicine·Satyendra MishraKrishna Misra
Sep 5, 2007·Assay and Drug Development Technologies·Biji T KurienR Hal Scofield
May 3, 2012·International Journal of Cell Biology·Luke R K HughsonJulian J Lum
Apr 29, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Shuai DongKui Wang
Sep 8, 2009·Biochemical Pharmacology·Hoda M EidLouis C Martineau
Sep 9, 2008·Biochemical Pharmacology·Preetha AnandBharat B Aggarwal
Aug 29, 2006·Biochemical Pharmacology·Waylon M WeberDavid L Vander Jagt
Aug 7, 2013·Journal of Receptor and Signal Transduction Research·Estelle HirzelAlex N Eberle
Sep 1, 2009·Biochemical and Biophysical Research Communications·Han Wern LimKim Ping Wong
Jun 12, 2016·European Journal of Pharmacology·Yapeng LuLi Zhu
Jul 5, 2005·Bioorganic & Medicinal Chemistry Letters·Ho Bum WooChan Mug Ahn
Mar 28, 2017·ChemMedChem·Valentina Noemi MadiaRoberta Costi
Jul 5, 2005·Molecular Nutrition & Food Research·Lydia PanClarissa Gerhäuser
Oct 19, 2017·International Journal of Molecular Medicine·Wenjuan TangYan Bi
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla I NietoJosé Luis Lavandera
Dec 31, 2020·PloS One·Iliuza R IaubasarovaYuri N Antonenko
Mar 31, 2021·Molecular Metabolism·Riya ShresthaFrances L Byrne