Fluoride dose-response of human and bovine enamel artificial caries lesions under pH-cycling conditions

Clinical Oral Investigations
Frank Lippert, Kalp Juthani

Abstract

This laboratory study aimed to (a) compare the fluoride dose-response of different caries lesions created in human and bovine enamel (HE/BE) under pH-cycling conditions and (b) investigate the suitability of Knoop and Vickers surface microhardness (K-SMH/V-SMH) in comparison to transverse microradiography (TMR) to investigate lesion de- and remineralization. Caries lesions were formed using three different protocols (Carbopol, hydroxyethylcellulose-HEC, methylcellulose-MeC) and assigned to 24 groups using V-SMH, based on a 2 (enamel types) × 3 (lesion types) × 4 (fluoride concentrations used during pH-cycling-simulating 0/250/1100/2800 ppm F as sodium fluoride dentifrices) factorial design. Changes in mineral content and structural integrity of lesions were determined before and after pH-cycling. Data were analyzed using three-way ANOVA. BE was more prone to demineralization than HE. Both enamel types showed similar responses to fluoride with BE showing more remineralization (as change in integrated mineral loss and lesion depth reduction), although differences between tissues were already present at lesion baseline. Carbopol and MeC lesions responded well to fluoride, whereas HEC lesions were almost inert. K- and V-SMH correla...Continue Reading

References

Jan 1, 1979·Caries Research·J ArendsW G Jongebloed
Jul 4, 1975·Calcified Tissue Research·J Arends, C L Davidson
Apr 1, 1992·Journal of Dental Research·F SchäferT A Parr
Jul 1, 1987·Physics in Medicine and Biology·E de Josselin de JongJ Noordmans
Jan 1, 1980·Caries Research·J ArendsW G Jongebloed
Oct 3, 1998·Archives of Oral Biology·B T AmaechiW M Edgar
Feb 1, 1963·Journal of Ultrastructure Research·B ANGMARJ E GLAS
Mar 10, 2004·The Journal of the American Dental Association·D T ZeroM Hoffman
Sep 9, 2004·Archives of Oral Biology·Rodrigo Borges FonsecaCarlos José Soares
Oct 26, 2006·Journal of Dental Research·A Z AbdullahM S Duggal
Aug 5, 2008·Archives of Oral Biology·R B FonsecaL Correr-Sobrinho
Feb 11, 2010·Microscopy Research and Technique·A E Souza-GabrielS A M Corona
Mar 3, 2011·Journal of Biomedical Optics·David ChurchleyCarlos Gonzalez-Cabezas
Apr 26, 2013·Caries Research·B T AmaechiT Nakamoto

❮ Previous
Next ❯

Citations

Mar 20, 2016·Clinical Oral Investigations·M Esteves-OliveiraJ A Rodrigues
Apr 12, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Ehab Z AlsayedAlireza Sadr
Mar 23, 2018·Dentistry Journal·Grace Gomez Felix GomezRichard L Gregory
Oct 28, 2017·Materials·Ollie Yiru YuChun-Hung Chu
Jan 19, 2018·Clinical Oral Investigations·R J WierichsM Esteves-Oliveira
Jan 11, 2019·Operative Dentistry·B R KimB I Kim
Apr 22, 2017·International Journal of Dentistry·Frank Lippert
Jul 22, 2018·Frontiers in Physiology·Jinpu ChuQun Zhang
Oct 12, 2018·Clinical Oral Investigations·Carolin WaltherRichard Johannes Wierichs
Dec 15, 2019·Dentistry Journal·Grace Gomez Felix GomezRichard L Gregory
Sep 15, 2017·Journal of Oral Science·Sumalee BoonviriyaSuwanna Jitpukdeebodintra
Nov 30, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Ollie Yiru YuChun-Hung Chu
Nov 28, 2019·Caries Research·Richard J WierichsMarcella Esteves-Oliveira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.