Fluoride Exposure in Early Life as the Possible Root Cause of Disease In Later Life

The Journal of Clinical Pediatric Dentistry
Tetsuo Nakamoto, H Ralph Rawls

Abstract

Fluoride, one of the most celebrated ingredients for the prevention of dental caries in the 20th century, has also been controversial for its use in dentifrices and other applications. In the current review, we have concentrated primarily on early-life exposure to fluoride and how it may affect the various organs. The most recent controversial aspects of fluoride are related to toxicity of the developing brain and how it may possibly result in the decrease of intelligence quotient (IQ), autism, and calcification of the pineal gland. In addition, it has been reported to have possible effects on bone and thyroid glands. If nutritional stress is applied during a critical period of growth and development, the organ(s) and/or body will never recover once they pass through the critical period. For example, if animals are force-fed during experiments, they will simply get fat but never reach the normal size. Although early-life fluoride exposure causing fluorosis is well reported in the literature, the dental profession considers it primarily as an esthetic rather than a serious systemic problem. In the current review, we wanted to raise the possibility of future disease as a result of early-life exposure to fluoride. It is not curren...Continue Reading

References

Mar 1, 1975·Pediatric Research·E M Widdowson, R A McCance
Jan 1, 1992·Journal of Public Health Dentistry·H NaccacheP M Bernard
Nov 1, 1991·Clinical Pediatrics·P L SimardJ M Brodeur
Nov 1, 1991·Neurotoxicology and Teratology·R N Hughes, I J Beveridge
Sep 1, 1990·Medical Hypotheses·J T ChanA H Jeske
May 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·J T ChanJ G Weatherred
Dec 1, 1988·Journal of Dental Research·O O OsujiN Levine
Sep 1, 1971·The Journal of Pathology·E Tapp, M Huxley
Jan 1, 1972·Bibliotheca nutritio et dieta·E M Widdowson
Jul 1, 1966·The Journal of Nutrition·M Winick, A Noble
Sep 30, 1966·Science·R J Goss
Oct 23, 1995·Proceedings. Biological Sciences·D J Barker
Dec 1, 1995·American Journal of Public Health·K H GelbergR Dubrow
Mar 1, 1995·Neurotoxicology and Teratology·P J MullenixW J Kernan
Jun 1, 1994·Community Dentistry and Oral Epidemiology·S M Levy
Jan 1, 1996·Caries Research·J T Chan, S H Koh
Jul 1, 1996·Journal of Dental Research·N Guha-ChowdhuryA C Smillie
Jul 1, 1997·Journal of Public Health Dentistry·J D Shulman, L M Wells
Oct 7, 1998·Neurotoxicology and Teratology·Z Z GuanG Dallner
Aug 19, 1999·The New England Journal of Medicine·J E HaddowR Z Klein
Jan 14, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D KunzW M Herrmann
Jan 2, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C RobinsonJ Kirkham
Mar 29, 2001·Caries Research·J Luke
Jul 28, 2001·Journal of Public Health Dentistry·S M LevyJ S Wefel
Nov 13, 2001·Clinical and Experimental Pharmacology & Physiology·R Morley, T Dwyer
Apr 18, 2002·Calcified Tissue International·C CooperN Arden
Feb 22, 2003·Journal of Exposure Analysis and Environmental Epidemiology·Shih-Chun Candice LungKuang-Mao Chiang
Jan 1, 1962·Acta Anatomica·J R TROTT
Jan 1, 2005·Environmental Health Perspectives·Serap Erdal, Susan N Buchanan
Apr 6, 2006·Cancer Causes & Control : CCC·Elise B BassinMurray A Mittleman
Dec 19, 2006·Lancet·P Grandjean, P J Landrigan
Jan 30, 2008·Scientific American·Dan Fagin
Apr 19, 2008·Health & Place·Patricia O'CampoJessica Burke
Apr 25, 2009·Biological Trace Element Research·R SandhuS Kharb
Jul 21, 2009·Pediatric Blood & Cancer·Rachel EyreRichard J Q McNally
Jul 24, 2012·Environmental Health Perspectives·Anna L ChoiPhilippe Grandjean
Jan 1, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alvin C BronsteinRichard C Dart
Jun 14, 2013·Journal of Public Health Management and Practice : JPHMP·Matthew C FarrellyJane A Allen
Feb 22, 2014·Lancet Neurology·Philippe Grandjean, Philip J Landrigan
Jan 13, 2015·The Journal of Clinical Pediatric Dentistry·N Pérez-PérezM E Irigoyen-Camacho
Jul 23, 2015·Community Dentistry and Oral Epidemiology·Pradeep BhagavatulaJohn J Warren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Gigiena i sanitariia
T A NIKOLAEVA, A S BELITSKII
Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
Vineet Dhar, Maheep Bhatnagar
© 2022 Meta ULC. All rights reserved