PMID: 40394Aug 1, 1979

Fluoride inhibition of protein and DNA synthesis in cells in vitro

Acta Pharmacologica Et Toxicologica
R I Holland


Fluoride concentrations at and above 0.9 mM caused a progressive, concentration-related inhibition in the incorporation of both 14C-leucine and 3H-thymidine in LS cells incubated in medium with serum. The incorporation of leucine was more affected than that of thymidine. Lowering the pH enhanced the effect of fluoride on both. Removing serum from the incubation medium changed the effect of fluoride, particularly at low pH (7.0). Incorporation of leucine was then stimulated by low fluoride concentrations (0.5 and 0.9 mM), and the effect on thymidine incorporation was eradicated up to 1.3 mM-NaF. No differences were found in the pool and the specific activity of 14C-leucine in the fluoride exposed cells compared to control cells without fluoride (incubated at pH 7.4 in medium without serum). The cellular pool of 3H-thymidine decreased markedly during the incubation period, somewhat less in the fluoride exposed cells than in the control.


Jan 1, 1980·Acta Pharmacologica Et Toxicologica·C F HongsloR I Holland
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Sep 17, 2008·Environmental Health Perspectives·Ramaswamy SharmaJohn D Bartlett
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Jan 1, 1993·Environmental and Molecular Mutagenesis·E ZeigerK L Witt
Dec 29, 2004·Brazilian Oral Research·Daniel Araki RibeiroDaisy Maria Fávero Salvadori
Nov 1, 1983·Acta Pharmacologica Et Toxicologica·R I Holland
Jul 20, 2010·International Journal of Molecular Sciences·José A Morales-GonzálezManuel García-Luna Y González-Rubio


Jan 1, 1977·Archives of Oral Biology·J EkstrandS Rosell
May 1, 1979·Acta Pharmacologica Et Toxicologica·R I Holland, J K Hongslo
May 1, 1979·Acta Pharmacologica Et Toxicologica·R I Holland, J K Hongslo
Mar 1, 1978·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·R MankovitzM Florian
Sep 1, 1978·Acta Pharmacologica Et Toxicologica·R I Holland, J K Hongslo
Sep 1, 1978·Acta Pharmacologica Et Toxicologica·J K Honglso, I Alfheim
Sep 1, 1976·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B J LinE M Nagy
Aug 1, 1973·The Journal of Cell Biology·R Hand, I Tamm
Mar 1, 1974·Journal of Dental Research·J K HongsloJ Jonsen
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Jan 1, 1969·Cold Spring Harbor Symposia on Quantitative Biology·C BaglioniM Jacobs-Lorena
Aug 28, 1964·Science·W R PROFFIT, J L ACKERMAN

Related Concepts

Fluoride Measurement
Protein Biosynthesis
Metabolic Inhibition
DNA Biosynthetic Process
DNA Replication

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