PMID: 8968033Dec 1, 1996Paper

Fluoride pharmacokinetics and changes in lumbar spine and hip bone mineral density

Bone
S PatelD J Hosking

Abstract

Debate about the use of fluoride for the treatment of vertebral osteoporosis has centered not only on whether fluoride treatment decreases vertebral fractures, but also the interindividual vertebral bone mineral density (BMD) response, the potential for nonvertebral fractures, as well as side effects and tolerability. These effects may be dose dependent and, in this study, we examine the pharmacokinetics of sodium monofluorophosphate (MFP) in osteoporotic patients and relate this to changes in BMD. Plasma fluoride absorption curves were measured from 0 to 6 h after ingestion of MFP at baseline and during long-term dosing in 21 patients with vertebral osteoporosis (T scores < or = 2). BMD was measured at baseline and at 12 months at the lumbar spine (LS), femoral neck (FN), trochanter, and Ward's triangle. We found that fluoride elimination was inversely related to creatinine clearance. LS BMD increased from a median of 0.77 g/cm2 (range 0.69 to 0.99) at baseline to 0.88 g/cm2 (0.75 to 1.13) (p < 0.001) after 12 months. This equates to a median increase of 12% (range -1.2 to 37). Median femoral neck BMD decreased from 0.75 g/cm2 (0.62 to 0.94) at baseline to 0.69 g/cm2 (0.62 to 0.92) (p = 0.13) after 12 months. This equates to a...Continue Reading

References

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Citations

Feb 24, 2001·Journal of the American Dietetic Association
Feb 22, 2008·Journal of Gastroenterology and Hepatology·Prabhleen ChahalKeith D Lindor
Dec 22, 2006·The Science of the Total Environment·Mehmet Numan TamerMustafa Yildiz
Oct 24, 2000·Journal of the American Dietetic Association
Aug 9, 2001·Australian Dental Journal·L L DemosC K Fairley

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