PMID: 9437512Jan 23, 1998Paper

Fluoride potentiates the osteogenic effects of IGF-I in aged ovariectomized rats

Bone
P AmmannJ P Bonjour

Abstract

The molecular mechanisms whereby fluoride stimulates osteogenic cell proliferation are not clearly established. However, fluoride has been shown to enhance the protein tyrosine phosphorylation of various constituents of intracellular signaling cascades in osteoblastic cells following stimulation of growth factor receptors such as the insulin-like growth factor-I (IGF-I) receptor. Such in vitro findings provided the rationale for testing whether the administration of fluoride could enhance IGF-I effects on bone mass in vivo. Adult ovariectomized osteopenic rats were treated with sodium fluoride at a dose of 6 mg/kg per day in drinking water for 8 weeks in association with IGF-I either at a dose of 2 mg/kg per day, which is capable of increasing bone mass, or at a lower dose without detectable skeletal effects. Bone mineral density (BMD) and content (BMC) were evaluated by dual-energy X-ray absorptiometry at the levels of the lumbar spine and proximal, midshaft, and total tibia before and after 8 weeks of treatment. During this period, fluoride alone did not significantly influence BMD/BMC at any skeletal site. However, it potentiated the effect of the higher dose of IGF-I on bone mass at the level of the proximal tibia. When adm...Continue Reading

References

May 1, 1992·Calcified Tissue International·M W LundyD J Baylink
Feb 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J M PouillesC Ribot
Oct 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P ChavassieuxP J Meunier
Nov 1, 1990·Bone and Mineral·P T Cheng, S M Bader
Mar 22, 1990·The New England Journal of Medicine·B L RiggsL J Melton
Aug 1, 1995·Journal of Dental Research·C H TurnerA J Dunipace
May 1, 1995·Calcified Tissue International·D J BaylinkT A Einhorn
Dec 1, 1994·Calcified Tissue International·D M Raab-CullenR R Recker
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P AmmannJ P Bonjour

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Citations

Aug 9, 2012·Biological Trace Element Research·Chun-Yan HuHui Xu
Nov 15, 2001·Joint, Bone, Spine : Revue Du Rhumatisme·R RizzoliJ P Bonjour
Mar 19, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J P BonjourR Rizzoli
Nov 3, 2012·International Journal of Biomaterials·Marta MonjoJan Eirik Ellingsen
Dec 22, 2006·The Science of the Total Environment·Mehmet Numan TamerMustafa Yildiz

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