PMID: 3214678Oct 1, 1988Paper

Fluoride reduces the rate of dissolution of bone

Bone and Mineral
M D Grynpas, P T Cheng

Abstract

Recently, fluoride has been used in the treatment of osteoporosis in an attempt to rebuild bone lost due to this disease. Fluoride has been shown to have a profound effect on osteoblasts and bone formation. Studies have shown that synthetic fluorapatite is more stable and less soluble than hydroxyapatite. This study was designed to determine the dissolution properties of bones from rats fed a normal diet versus rats fed a high fluoride diet. Intact and deproteinized bones were dissolved in buffered solutions, containing physiological amounts of inorganic Ca and P, at pH 3.4, 4.4 and 5.4. The data demonstrate that fluoridated bones dissolve slower than normal bones, deproteinized bones dissolve faster than intact bones and that the initial rate of dissolution of fluoridated bone is always significantly lower than that of normal bone. This may help to explain the reduced rate of osteoclastic resorption in patients undergoing fluoride therapy.

References


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Citations

Feb 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M SchnitzlerA E Smyth
Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M D Grynpas
Jan 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P T ChengK Müller
Mar 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M D GrynpasJ M Very
Jan 1, 1993·Calcified Tissue International·M Grynpas
Oct 1, 1990·Calcified Tissue International·J B Kopp, P G Robey
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Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·R J van't HofS H Ralston
May 1, 1992·Kidney International·T H IttelH G Sieberth
Nov 1, 1990·Bone and Mineral·P T Cheng, S M Bader
Apr 1, 1996·Critical Reviews in Clinical Laboratory Sciences·M Kleerekoper
Apr 10, 2007·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Mark KebschM Ali Darendeliler
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Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M S Johnsson, G H Nancollas
Jun 1, 1994·Advances in Dental Research·M Kleerekoper

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