PMID: 9192519Jul 1, 1997Paper

Fluoride treatment increased serum IGF-1, bone turnover, and bone mass, but not bone strength, in rabbits

Calcified Tissue International
C H TurnerG K Stookey

Abstract

We hypothesized that fluoride partly acts by changing the levels of circulating calcium-regulating hormones and skeletal growth factors. The effects of oral fluoride on 24 female, Dutch-Belted, young adult rabbits were studied. The rabbits were divided into two study groups, one control and the other receiving about 16 mg fluoride/rabbit/day in their drinking water. After 6 months of fluoride dosing, all rabbits were euthanized and bone and blood samples were taken for analyses. Fluoride treatment increased serum and bone fluoride levels by over an order of magnitude (P < 0.001), but did not affect body weight or the following serum biochemical variables: urea, creatinine, phosphorus, total protein, albumin, bilirubin, SGOT, or total alkaline phosphatase. No skeletal fluorosis or osteomalacia was observed histologically, nor did fluoride affect serum PTH or Vitamin D metabolites (P > 0.4). BAP was increased 37% (P < 0.05) by fluoride; serum TRAP was increased 42% (P < 0.05); serum IGF-1 was increased 40% (P < 0.05). Fluoride increased the vertebral BV/TV by 35% (P < 0.05) and tibial ash weight by 10% (P < 0.05). However, the increases in bone mass and bone formation were not reflected in improved bone strength. Fluoride decreas...Continue Reading

Citations

Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C H Turner
Jan 22, 2010·Journal of Bone and Mineral Metabolism·Delphine FarlayGeorges Boivin
Sep 29, 2011·Journal of Bone and Mineral Metabolism·Subarayan Bothi Gopalakrishnan, Gopalan Viswanathan
Nov 17, 2009·Biological Trace Element Research·Hui XuGuang-Sheng Li
Jul 23, 2013·Biological Trace Element Research·Xiao ChenZhongqiu Wang
Feb 24, 2001·Journal of the American Dietetic Association
Jan 11, 2002·Journal of Biomechanics·Timo JämsäJuha Tuukkanen
Jun 12, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Isabelle SiroisWendy E Ward
Aug 15, 2001·Bone·M C van der MeulenB Mikić
Dec 12, 2012·The British Journal of Nutrition·Priyanka ShankarArjun L Khandare
Oct 19, 2005·Journal of Biomedical Optics·Adele Boskey, Richard Mendelsohn
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J TuukkanenS C Marks
Nov 5, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Ersan Ilsay KaradenizM Ali Darendeliler
Feb 9, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Carmen GonzalesNoriaki Yoshida
Dec 18, 2015·International Journal of Oral Science·Ujjal K BhawalKoh Shibutani
Oct 24, 2000·Journal of the American Dietetic Association
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Michael DermiencePhilippe Goyens
Nov 13, 2012·American Journal of Obstetrics and Gynecology·Angelo A Licata
Aug 22, 2006·Bone·M MousnyM D Grynpas
Feb 8, 2006·Clinical Orthopaedics and Related Research·Dan FaibishAdele L Boskey
Jan 16, 2007·Skeletal Radiology·Roger T TomihamaAndrew H Haims
Jan 5, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M L BouxseinUNKNOWN IOF Working Group on Hip Bone Strength as a Therapeutic Target
Mar 20, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Ivana ZofkováPetr Matucha
Jan 3, 2019·Biological Trace Element Research·Yingjie YaoJunrui Pei
Aug 10, 2020·Biological Trace Element Research·Priyanka ShankarSujata Khandare
Aug 9, 2001·Australian Dental Journal·L L DemosC K Fairley
May 4, 2021·Biological Trace Element Research·Rui LiZilong Sun
Aug 21, 2021·Current Osteoporosis Reports·Asier MuñozAlessandra Carriero

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