Fluorinated psychopharmacological agents: noninvasive observation by fluorine-19 nuclear magnetic resonance

Psychiatry Research
M BartelsM Zabel

Abstract

Fluorinated psychopharmacological agents were measured with fluorine-19 nuclear magnetic resonance spectroscopy in the brain of intact rats that had been treated with fluphenazine. These in vivo experiments were compared to in vitro measurements of fluphenazine-treated rats. A high-field shift was observed in both in vivo and in vitro measurements. On the basis of the in vitro measurements, fluphenazine concentration in the brains of treated rats was estimated. Our observations demonstrate the feasibility of this technique for determining fluorinated neuroleptics in live mammals.

Citations

Feb 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A KomoroskiC N Karson
Jan 1, 1995·Journal of Neural Transmission. General Section·M Bartels, K Albert
Apr 1, 1991·Biological Psychiatry·R A KomoroskiJ Sprigg
Jul 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·T J PasseK R Krishnan
Jun 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M C Malet-Martino, R Martino
Dec 1, 1988·Clinical Physiology·O HenriksenC Thomsen

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