Fluorinated quinoid inhibitor: possible "pure" arylator predicted by the simple theoretical calculation

Bioorganic & Medicinal Chemistry Letters
Seung W HamBrian I Carr

Abstract

We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.

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Citations

Feb 19, 2014·Medical Gas Research·Dragic VukomanovicKanji Nakatsu
Jun 6, 2009·Chemico-biological Interactions·Daniela M SantosCecília M P Rodrigues
Jun 9, 2017·Chemical Research in Toxicology·Shaojun YangJeffrey D Laskin
Sep 13, 2005·Molecular Pharmacology·Marni BrissonJohn S Lazo
May 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio Córdova-RivasJesús Adrián López
Nov 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ernesto Rivera-ÁvalosLluvia López
May 4, 2013·The Journal of Biological Chemistry·Shaojun YangJeffrey D Laskin
May 29, 2007·Bioorganic & Medicinal Chemistry·Cláudia ValenteKenneth T Douglas

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