PMID: 9169578Jun 1, 1997Paper

Fluorine-18 fluorodeoxyglucose positron emission tomography in the differential diagnosis of pancreatic carcinoma: a report of 106 cases

European Journal of Nuclear Medicine
M ZimnyU Buell

Abstract

The aim of this study was to evaluate fluorine-18 fluorodeoxyglucose positron emission tomography ([18F]FDG PET) as a tool for the differential diagnosis of pancreatic carcinoma while taking into account serum glucose level. A group of 106 patients with unclear pancreatic masses were recruited for the study. PET was performed following intravenous administration of an average of 190 MBq [18F]FDG. Focally increased glucose utilisation was used as the criterion of malignancy. In addition, the "standardised uptake value" (SUV) was determined 45 min after injection. Carcinoma of the pancreas was demonstrated histologically in 74 cases, and chronic pancreatitis in 32 cases. Employing visual evaluation, 63 of the 74 (85%) pancreatic carcinomas were identified by PET. In 27 of the 32 cases (84%) of chronic pancreatitis it was possible to exclude malignancy. False-negative results (n=11) were obtained mostly in patients with raised serum glucose levels (10 out of 11), and false-positives (n=5) in patients with inflammatory processes of the pancreas. Thus PET showed an overall sensitivity of 85%, a specificity of 84%, a negative predictive value of 71%, and a positive predictive value of 93%. In a subgroup of patients with normal serum ...Continue Reading

References

Jan 1, 1995·European Journal of Nuclear Medicine·T KatoT Ishigaki
Dec 1, 1996·European Journal of Nuclear Medicine·P RigoJ Foidart-Willems

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Citations

Sep 30, 1999·Gastroenterology Clinics of North America·P C Freeny
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H YoungP Price
Oct 1, 2003·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·Christoph G. DiederichsSven Norbert Reske
Apr 9, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Lioe-Fee de Geus-Oei, Wim J G Oyen
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·P C Freeny
Apr 22, 2003·AJR. American Journal of Roentgenology·Eric P TammDouglas B Evans
Jul 24, 2003·AJR. American Journal of Roentgenology·Mannudeep K KalraAlan J Fischman
Dec 16, 2011·World Journal of Gastroenterology : WJG·Elizabeth C Smyth, Manish A Shah
Mar 18, 2011·World Journal of Gastroenterology : WJG·Chakshu SharmaMichele Molinari
Aug 8, 2013·World Journal of Gastroenterology : WJG·Zhen WangYuan Huang
Aug 19, 2011·Indian Journal of Endocrinology and Metabolism·Vikas Chaudhary, Shahina Bano
Apr 24, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A P RijkersC H J van Eijck
Jan 29, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ippei MatsumotoYonson Ku
May 9, 2012·Radiologic Clinics of North America·Rocio Perez-JohnstonDushyant V Sahani
Jan 19, 2016·Critical Reviews in Oncology/hematology·Angela LamarcaJuan W Valle
Nov 18, 2011·Revista española de medicina nuclear e imagen molecular·S MirpourA H Khandani
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Dominique Delbeke, William H Martin
Feb 18, 2010·Surgical Oncology Clinics of North America·Dominique Delbeke, William H Martin
Aug 18, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hiroyuki MatsubayashiHiroyuki Ono
Jul 1, 2008·PET Clinics·Roland HustinxGauthier Namur
Apr 1, 2008·PET Clinics·Dominique Delbeke, William H Martin
Nov 16, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J RufH Amthauer
Dec 1, 2004·Alimentary Pharmacology & Therapeutics·L A OrlandoD B Matchar
Dec 24, 2004·Surgical Oncology·Susannah ShorePaula Ghaneh
Jun 10, 2006·Seminars in Nuclear Medicine·Farrokh PakzadPeter J Ell
Aug 6, 2000·Seminars in Nuclear Medicine·R Bar-ShalomM D Blaufox
Feb 14, 2006·Best Practice & Research. Clinical Gastroenterology·Bennett B Chin, Paul P L Chang
Aug 23, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ivan BorbathPierre H Deprez
Jun 29, 2005·Nuclear Medicine and Biology·Mariëtte C A van KouwenJoost P H Drenth
Oct 19, 2004·Radiologic Clinics of North America·Roland Hustinx
Apr 28, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Juri RufHolger Amthauer
Mar 15, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Mathieu GauthéUNKNOWN Fédération Francophone de Cancérologie Digestive (FFCD)
Sep 7, 2016·Pharmacology & Therapeutics·Karen M MannNeal G Copeland
Jun 8, 2001·The Surgical Clinics of North America·R L van Heertum, R A Fawwaz
Oct 18, 2007·Radiology·Daniel J A MargolisSanjiv S Gambhir

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