Fluorine 18-tagged fluorodeoxyglucose positron emission tomographic scanning to predict lymph node metastasis, invasiveness, or both, in clinical T1 N0 M0 lung adenocarcinoma

The Journal of Thoracic and Cardiovascular Surgery
Hiroaki NomoriKimiichi Uno

Abstract

We sought to predict lymph node metastasis and tumor invasiveness in clinical T1 N0 M0 lung adenocarcinomas, and we measured fluorodeoxyglucose uptake on positron emission tomography. Fluorodeoxyglucose positron emission tomography was performed on 44 patients with adenocarcinomas of 1 to 3 cm in size clinically staged as T1 N0 M0 before major lung resection with lymph node dissection. Fluorodeoxyglucose uptake was evaluated by using the contrast ratio between the tumor and contralateral healthy lung tissue. Lymphatic and vascular invasion within tumors, pleural involvement, and grade of histologic differentiation were examined. The pathologic tumor stage was T1 N0 M0 in 36 patients, and a more advanced stage was found in 8 patients. Although all 22 adenocarcinomas with a contrast ratio of less than 0.5 in fluorodeoxyglucose uptake were pathologic T1 N0 M0 tumors, 8 (36%) of 22 with a contrast ratio of 0.5 or greater were of a more advanced stage than T1 N0 M0, with the difference being significant (P =.002). Adenocarcinomas with a contrast ratio of less than 0.5 showed less lymphatic and vascular invasion and less pleural involvement than those with a contrast ratio of 0.5 or greater (P =.006, P =.004, and P =.02, respectively...Continue Reading

References

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Citations

Mar 16, 2005·Diseases of the Colon and Rectum·Khaled M MadboulyIan C Lavery
Apr 16, 2009·General Thoracic and Cardiovascular Surgery·Hiroaki NomoriTakeshi Mori
Apr 1, 2007·Annals of Thoracic Medicine·Vahid Reza Dabbagh Kakhki
Apr 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Takeshi MoriYasuyuki Yamashita
Jan 1, 2013·The Annals of Thoracic Surgery·Lorenzo SpaggiariJuliana Guarize
Jul 16, 2010·European Journal of Radiology·Thomas HenzlerChristian Fink
Nov 29, 2013·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Takayuki KosakaHiroyuki Kuwano
Dec 13, 2007·Thoracic Surgery Clinics·Eugene H Blackstone, Thomas W Rice
Aug 9, 2015·Annals of Nuclear Medicine·Katsuhiko ShimizuMasao Nakata
Sep 9, 2004·The Journal of Thoracic and Cardiovascular Surgery·Eugene H Blackstone, Michael S Lauer
Jun 28, 2005·Journal of the American College of Surgeons·Joseph B ZwischenbergerJuan C Escalon
Mar 22, 2008·The Annals of Thoracic Surgery·Benjamin D KozowerJoe B Putnam
Apr 5, 2011·European Journal of Radiology·Valentina AmbrosiniStefano Fanti
Jun 14, 2006·Journal of Thoracic Imaging·John F Bruzzi, Reginald F Munden
Nov 29, 2008·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Kyung Min ShinKeunchil Park

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