Fluoro-Photoacoustic Polymeric Renal Reporter for Real-Time Dual Imaging of Acute Kidney Injury

Advanced Materials
Penghui ChengKanyi Pu

Abstract

Photoacoustic (PA) imaging agents detect disease tissues and biomarkers with increased penetration depth and enhanced spatial resolution relative to traditional optical imaging, and thus hold great promise for clinical applications. However, existing PA imaging agents often encounter the issues of slow body excretion and low-signal specificity, which compromise their capability for in vivo detection. Herein, a fluoro-photoacoustic polymeric renal reporter (FPRR) is synthesized for real-time imaging of drug-induced acute kidney injury (AKI). FPRR simultaneously turns on both near-infrared fluorescence (NIRF) and PA signals in response to an AKI biomarker (γ-glutamyl transferase) with high sensitivity and specificity. In association with its high renal clearance efficiency (78% at 24 h post-injection), FPRR can detect cisplatin-induced AKI at 24 h post-drug treatment through both real-time imaging and optical urinalysis, which is 48 h earlier than serum biomarker elevation and histological changes. More importantly, the deep-tissue penetration capability of PA imaging results in a signal-to-background ratio that is 2.3-fold higher than NIRF imaging. Thus, the study not only demonstrates the first activatable PA probe for real-tim...Continue Reading

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Citations

Sep 6, 2020·International Journal of Molecular Sciences·Gengqi LiuYumiao Zhang
Dec 20, 2020·International Journal of Pharmaceutics·Zhongxiong FanZhenqing Hou
Feb 9, 2021·Advanced Science·Huangxuan ZhaoChengbo Liu
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Jun 29, 2021·Analytical Chemistry·Xiaoxia ChenZijuan Hai
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Apr 4, 2020·Analytical Chemistry·Penghui ChengKanyi Pu
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Sep 9, 2021·Nanoscale·Qiaochu JiangXianbao Sun
Sep 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Melissa Y LuceroJefferson Chan

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