Fluoroalkyl sulfides as photoredox-active coupling reagents for alkene difunctionalization.

Chemical Communications : Chem Comm
Mikhail D KosobokovAlexander D Dilman

Abstract

A visible-light-promoted fluoroalkylation-thiolation of alkenes is described. A 4-tetrafluoropyridinylthio fragment serves as a photoredox-active group in the initiation step and undergoes a radical group transfer, which is important for the reaction efficiency. In the primary products, the pyridinylthio substituent may be further functionalized via radical processes or an aromatic substitution reaction.

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Citations

Nov 5, 2020·Angewandte Chemie·Liubov I PanferovaAlexander D Dilman
Apr 29, 2021·Chemical Communications : Chem Comm·Vladislav S KostromitinAlexander D Dilman
May 1, 2021·Organic Letters·Liubov I Panferova, Alexander D Dilman

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Methods Mentioned

BETA
NMR

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