PMID: 178265Mar 1, 1976Paper

Fluorocitrate ototoxicity. A morphologic and cytochemical model for primary neural degeneration in the guinea pig cochlea

The Annals of Otology, Rhinology, and Laryngology
G J Spector, C D Carr


Fluorocitrate, an inhibitor of the tricarboxylic acid cycle at the aconitase reaction, produces a time and dose related neural dystrophy in the guinea pig cochlea. There is direct inhibition of succinic dehydrogenase activity but not nicotinamide adenine dinucleotide dehydrogenase and cytochrome oxidase via cytochrome c activities. The dystrophic neural changes morphologically are similar to those noted in primary neural degeneration and neural presbycusis in man. Neural degeneration in aging appears to be the result of a dissociation of biochemical reactions preventing the proper utilization of organic fuel molecules for generation of energy and direct or indirect inhibition of respiration.


May 1, 1971·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M SeligmanR E Plapinger
Jun 1, 1967·Archives of Otolaryngology·L G Johnsson, J E Hawkins
Apr 1, 1966·The Journal of Cell Biology·H D Fahimi, M J Karnovsky
Oct 1, 1974·The Laryngoscope·G J Spector, F E Lucente
Apr 1, 1972·The Annals of Otology, Rhinology, and Laryngology·L G Johnsson, J E Hawkins
Apr 1, 1971·Journal of Neurochemistry·A Patel, H Koenig
Feb 19, 1971·FEBS Letters·R V. BruntS A. Symons
Jun 1, 1953·The Laryngoscope·H F SCHUKNECHT, R C WOELLNER
Feb 1, 1957·The Laryngoscope·W P COVELL, J B ROGERS
Oct 1, 1964·Archives of Otolaryngology·H F SCHUKNECHT
Nov 1, 1964·Acta Oto-laryngologica·R S KIMURAI SANDO
Aug 1, 1965·Archives of Otolaryngology·C C HANSEN, E RESKE-NIELSEN
Feb 1, 1955·The Journal of Laryngology and Otology·H F SCHUKNECHT, R C WOELLNER
Jul 2, 1948·Science·A C Copisarow
Aug 1, 1947·Journal of Comparative and Physiological Psychology·E G WEVER, W D NEFF

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Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·E J LienL L Lien
Nov 1, 1976·The Annals of Otology, Rhinology, and Laryngology·G J Spector
Jan 1, 1993·Acta Oto-laryngologica·C A BuchmanJ D Swarts

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