PMID: 178265Mar 1, 1976Paper

Fluorocitrate ototoxicity. A morphologic and cytochemical model for primary neural degeneration in the guinea pig cochlea

The Annals of Otology, Rhinology, and Laryngology
G J Spector, C D Carr

Abstract

Fluorocitrate, an inhibitor of the tricarboxylic acid cycle at the aconitase reaction, produces a time and dose related neural dystrophy in the guinea pig cochlea. There is direct inhibition of succinic dehydrogenase activity but not nicotinamide adenine dinucleotide dehydrogenase and cytochrome oxidase via cytochrome c activities. The dystrophic neural changes morphologically are similar to those noted in primary neural degeneration and neural presbycusis in man. Neural degeneration in aging appears to be the result of a dissociation of biochemical reactions preventing the proper utilization of organic fuel molecules for generation of energy and direct or indirect inhibition of respiration.

References

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Citations

Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·E J LienL L Lien
Nov 1, 1976·The Annals of Otology, Rhinology, and Laryngology·G J Spector
Jan 1, 1993·Acta Oto-laryngologica·C A BuchmanJ D Swarts

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