Fluorogenic Diversification of Unprotected Bromotryptophan by Aqueous Mizoroki-Heck Cross-Coupling

Chemistry : a European Journal
Hendrik GrußNorbert Sewald

Abstract

Fluorescent styryl-tryptophans have been synthesized by a Mizoroki-Heck cross-coupling from unprotected bromotryptophan in aqueous medium showing promising spectrophotometric properties for possible application in fluorescence labelling of biomolecules. Moreover, this strategy permits a modular combination of biocatalytic halogenation by using immobilized FAD-dependent tryptophan halogenases and Pd-mediated chemocatalysis in a multistep one-pot process.

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Citations

Sep 4, 2019·Chembiochem : a European Journal of Chemical Biology·Isabell KemkerNorbert Sewald
Sep 24, 2019·Chemistry : a European Journal·Hendrik Gruß, Norbert Sewald
Oct 18, 2019·Frontiers in Bioengineering and Biotechnology·Kareen H VeldmannVolker F Wendisch
Apr 17, 2020·Chemistry : a European Journal·Elmira GhabraieNorbert Sewald
Jul 9, 2020·Chemistry : a European Journal·Steffen DachwitzNorbert Sewald
Jan 17, 2021·Angewandte Chemie·Elvira RomeroChristian Schnepel
Mar 18, 2020·Current Opinion in Chemical Biology·Xiaoqiang HuangHuimin Zhao
Dec 29, 2020·Journal of Medicinal Chemistry·Isabell KemkerNorbert Sewald
Oct 30, 2021·Chemistry : a European Journal·Steffen DachwitzNorbert Sewald

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