PMID: 837968Jan 3, 1977Paper

Fluorometric determination of hydroflumethiazide in human plasma and urine after its oral administration

European Journal of Clinical Pharmacology
O BrorsE Arnesen

Abstract

A spectrofluorometric method for determination of hydroflumethiazide in human plasma and urine has been developed. The limit of detection was 10 ng/ml plasma and 100 ng/ml urine. The plasma concentration of hydroflumethiazide was determined for 9-11 hours and excretion in urine for 24-37 hrs after oral administration of about 1 mg/kg body weight to 7 subjects. Plasma half life in healthy subjects was 1.9-2.1 h, and 2.7-8.6 h in patients during the period 4-9 hrs after dosing. Cumulative excretion in urine was 67-79% of the dose during 31-37 hrs in 6 subjects; one patient with renal disease was found to excrete only 25.8% of dose during 24 hours. Renal clearance of hydroflumethiazide was higher in the healthy subjects (0.29-0.44 1 h-1 kg-1) than in the patients (0.040-0.15 1 h-1 kg-1). Plasma half life of hydroflumethiazide was not closely correlated with renal clearance of the drug, which suggests that other factors may play a role in determining plasma half life.

References

Aug 1, 1975·Journal of Pharmaceutical Sciences·W J VandenheuvelF J Wolf
Nov 1, 1974·Journal of Pharmaceutical Sciences·Y GarceauJ Hasegawa
Oct 1, 1971·Postgraduate Medical Journal·D G BeeversJ E Harpur
Oct 22, 1965·Deutsche medizinische Wochenschrift·V Heimsoth, F Hartmann
Jun 7, 1958·Lancet·N A MATHESON, T N MORGAN
Sep 12, 1959·Lancet·C R BLAGG
Sep 12, 1959·Lancet·C J EDMONDS, G M WILSON
Aug 24, 1963·JAMA : the Journal of the American Medical Association·D E HUTCHEON, G B LEONARD
Jun 5, 1964·Deutsche medizinische Wochenschrift·F REUTTER, F SCHAUB
Sep 13, 1962·The New England Journal of Medicine·J W RUNYAN

Citations

Nov 9, 1978·European Journal of Clinical Pharmacology·O BrørsE Arnesen
Sep 1, 1979·European Journal of Clinical Pharmacology·O Brørs, S Jacobsen
May 21, 1979·European Journal of Clinical Pharmacology·O Brørs, S Jacobsen
May 21, 1979·European Journal of Clinical Pharmacology·O BrørsS Jacobsen
Feb 1, 1980·British Journal of Clinical Pharmacology·C W VoseG T McInnes
Nov 1, 1986·Biopharmaceutics & Drug Disposition·P G Welling
Jan 1, 2014·International Scholarly Research Notices·Donald J DeGraciaZhi-Feng Huang

Related Concepts

Half-Life
Diucardin
Study, Methodological
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