Fluoropyrimidine and platinum toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses

Pharmacogenomics
Jared M CampbellMatthew D Stephenson

Abstract

Fluoropyrimidine (FU) and platinum-based chemotherapies are greatly complicated by their associated toxicities. This umbrella systematic review synthesized all systematic reviews that investigated associations between germline variations and toxicity, with the aim of informing personalized medicine. Systematic reviews are important in pharmacogenetics where false positives are common. Four systematic reviews were identified for FU-induced toxicity and three for platinum. Polymorphisms of DPYD and TYMS, but not MTHFR, were statistically significantly associated with FU-induced toxicity (although only DPYD had clinical significance). For platinum, GSTP1 was found to not be associated with toxicity. This umbrella systematic review has synthesized the best available evidence on the pharmacogenetics of FU and platinum toxicity. It provides a useful reference for clinicians and identifies important research gaps.

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Citations

May 5, 2016·Cancer Chemotherapy and Pharmacology·Jared M CampbellMicah D J Peters
Sep 17, 2016·JBI Database of Systematic Reviews and Implementation Reports·Jared M Campbell
Jan 12, 2017·Clinical Pharmacology and Therapeutics·R RoncatoG Toffoli
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Methods Mentioned

BETA
genotyping

Software Mentioned

JBI
ProQuest
HuGE
Umbrella Review Assessment and Review of Information

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