Fluoroquinolone efflux mediated by ABC transporters

Journal of Pharmaceutical Sciences
Ana I AlvarezGracia Merino

Abstract

Quinolones and fluoroquinolones are broad spectrum bactericidal drugs, which are widely used in both human and veterinary medicine. These drugs can quite easily enter cells and are often used to treat intracellular pathogens. Some fluoroquinolones have been reported to undergo efflux, which could explain their low bioavailability. There is a growing need to understand resistance mechanisms to quinolones, involving for instance mutations or the action of efflux pumps. Several members of the ATP-binding cassette (ABC) drug efflux transporter family (MDR, MRP, ABCG2) significantly affect the pharmacokinetic disposition of quinolones. Active secretory mechanisms common to all fluoroquinolones have been suggested, as well as competition between fluoroquinolones at transporter sites. For grepafloxacin and its metabolites, MRP2 has been demonstrated to mediate biliary excretion. However, MDR1 is responsible for grepafloxacin intestinal secretion. Recently it has been shown that ciprofloxacin and enrofloxacin are efficiently transported ABCG2 substrates which are actively secreted into milk. It appears that multiple ABC transporters contribute to the overall secretion of fluoroquinolones. The objective of this work is to review the rec...Continue Reading

References

Oct 1, 1992·The Journal of Antimicrobial Chemotherapy·A Maxwell
Jan 1, 1992·Clinical Pharmacokinetics·K C LampM J Rybak
Feb 1, 1992·The Journal of Infectious Diseases·C X CaoT H Steinberg
Jan 1, 1990·Chemotherapy·R RohwedderH Scholl
Mar 1, 1990·Diagnostic Microbiology and Infectious Disease·R W RohwedderH Scholl
Jan 1, 1989·Clinical Pharmacokinetics·F SörgelU Stephan
Apr 1, 1987·Antimicrobial Agents and Chemotherapy·N H GeorgopapadakouG L Olson
Jan 1, 1994·Annual Review of Pharmacology and Toxicology·A Y Chen, L F Liu
Mar 1, 1993·British Journal of Pharmacology·N M GriffithsN L Simmons
Aug 1, 1997·British Journal of Pharmacology·M E CavetN L Simmons
Aug 12, 1999·Biological & Pharmaceutical Bulletin·M SasayaM Takada
Aug 24, 1999·British Journal of Pharmacology·S DautreyR Farinotti
Sep 21, 2000·The Journal of Antimicrobial Chemotherapy·P Ball
Dec 5, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·E C de LangeW Couet
Feb 24, 2001·International Journal of Antimicrobial Agents·P C Appelbaum, P A Hunter
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L R Peterson
Jan 18, 2002·Antimicrobial Agents and Chemotherapy·Kazumasa NaruhashiAkira Tsuji
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Hiroaki YamaguchiKen-ichi Inui
Mar 6, 2002·British Journal of Pharmacology·Simon Lowes, Nicholas L Simmons
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Ying Lan ZhaoTakaaki Hasegawa
Sep 11, 2002·The Lancet Infectious Diseases·David C Hooper
Oct 9, 2002·Current Protein & Peptide Science·Karin F K Ejendal, Christine A Hrycyna
Jan 22, 2003·Advanced Drug Delivery Reviews·Alfred H Schinkel, Johan W Jonker
Feb 7, 2003·Current Topics in Medicinal Chemistry·Karl Drlica, Muhammad Malik
Aug 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manthena V S VarmaRamesh Panchagnula
Mar 19, 2004·Survey of Ophthalmology·Joseph M Blondeau
May 8, 2004·The Journal of Pharmacology and Experimental Therapeutics·Hiroyuki SasabeYuichi Sugiyama
Nov 16, 2004·American Journal of Therapeutics·Vineet SikriAshim K Mitra
Feb 18, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cindy Q XiaLiang-Shang Gan
Mar 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F Van BambekeP M Tulkens
Apr 23, 2005·Toxicology and Applied Pharmacology·Elaine M LeslieSusan P C Cole
Sep 13, 2005·The Veterinary Journal·Marilyn MartinezRobert Walker
Nov 25, 2005·Current Drug Delivery·Hristos GlavinasBalázs Sarkadi
Jan 18, 2006·Drug Metabolism and Pharmacokinetics·Hiroyuki SasabeYuichi Sugiyama
Jan 26, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gracia MerinoJulio G Prieto
Feb 21, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yoshihisa ShitaraYuichi Sugiyama
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Jean-Michel MichotFrançoise Van Bambeke
Jul 19, 2006·Journal of Veterinary Pharmacology and Therapeutics·Mivis M PulidoAna I Alvarez
Jul 20, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tomohiro AndoYuichi Sugiyama

❮ Previous
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Citations

May 18, 2011·The Journal of Membrane Biology·C RibeiroP Gameiro
Dec 1, 2010·Archives of Pharmacal Research·Hee YiHo-Chul Shin
Sep 21, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·I S HaslamN L Simmons
Feb 4, 2009·Antimicrobial Agents and Chemotherapy·Julien BrillaultWilliam Couet
Aug 15, 2009·Drugs·Xian-Zhi Li, Hiroshi Nikaido
Jan 22, 2011·Veterinary Medicine International·Marcela Rebuelto, María Elena Loza
Jul 6, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Guillermo Moreno-SanzDaniele Piomelli
Jul 20, 2012·Expert Opinion on Drug Metabolism & Toxicology·Joomi LeeYoung-Ran Yoon
Mar 23, 2012·Expert Opinion on Drug Metabolism & Toxicology·Aditi MulgaonkarDouglas H Sweet
Nov 22, 2015·Biopharmaceutics & Drug Disposition·Hiroshi ArakawaTakuo Ogihara
Aug 26, 2011·International Journal of Pharmaceutics·Ramya Krishna VadlapatlaAshim K Mitra
Oct 5, 2010·Advanced Drug Delivery Reviews·Claudia C Wagner, Oliver Langer
Sep 27, 2015·Ecotoxicology and Environmental Safety·Mareen Graouer-BacartEmmanuel Guillon
Jul 22, 2008·Journal of Veterinary Pharmacology and Therapeutics·A M HaritovaJ Fink-Gremmels
Jun 8, 2011·Journal of Veterinary Pharmacology and Therapeutics·K L Mealey
Apr 18, 2008·European Journal of Pharmacology·Jan A Schrickx, Johanna Fink-Gremmels
Aug 19, 2016·Frontiers in Microbiology·Pierre-Louis ToutainPeter Lees
Sep 18, 2016·Advanced Drug Delivery Reviews·Yan LiJames W Paxton
Jul 10, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S H LeeC-K Shim
Mar 30, 2016·Antimicrobial Agents and Chemotherapy·Hiroyuki SasabeKen Umehara
Sep 25, 2018·Acta Microbiologica Et Immunologica Hungarica·Seyedeh Marzieh Jabbari ShiadehMarjan Rashidan
Jul 4, 2015·Stroke; a Journal of Cerebral Circulation·Dannielle ZierathKyra Becker
Mar 27, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Natalia UrzúaCarlos Errecalde
Oct 5, 2018·Frontiers in Microbiology·Kaitlyn M FergusonDerek M Foster
Aug 23, 2020·International Journal of Molecular Sciences·Gabriele StoccoGiuliana Decorti
Jun 18, 2017·The Veterinary Record·Nuno Silva, Margarida Sousa

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