Abstract
The low risk febrile neutropenic patients with Multinational Association for Supportive Care in Cancer (MASCC) score of more than 20 are recommended to be treated with fluoroquinolone-based oral treatment by the National Comprehensive Cancer Network (NCCN) guideline. This recommendation relies, at least partially, on the high sensitivity of the blood culture isolates to fluoroquinolone in clinical trials conducted in Western countries. Whether this also applies in middle or low income countries like China where antibiotic resistance is becoming prevalent recently has not been evaluated. All the positive blood culture results from January 2010 to December 2013 in the 2 large Chinese cancer centers were reviewed. The patients were included into the study with the following criteria: febrile neutropenia, solid tumor or lymphoma, MASCC score >20, positive blood cultures within two days of the onset of fever, and detailed treatment history. A total of 38 patients were included in this analysis. Two patients had polymicrobial bacteremia (Enterococcus faecalis and Flavimonas oryzihabitans). Other isolates included coagulase-negative staphylococcus, micrococcal species, viridans streptococci, Klebsiella pneumoniae, and Escherichia coli...Continue Reading
References
Jul 29, 1999·The New England Journal of Medicine·A FreifeldP A Pizzo
Jun 26, 2001·Clinical and Laboratory Haematology·Y ZaidiP Mahendra
Jun 25, 2003·Social Science & Medicine·Aryanti Radyowijati, Hilbrand Haak
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·María E SantolayaMarcela Zubieta
Oct 2, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lillian SungHilary A Llewellyn-Thomas
May 11, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E CastagnolaC Girmenia
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Johanna N Timmer-BonteVivianne C Tjan-Heijnen
Apr 11, 2006·Globalization and Health·Ruifang ZhangRichard J Zeckhauser
Apr 22, 2006·Cancer·Kenneth V I RolstonRobert S Benjamin
Aug 10, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A ComettaUNKNOWN Infectious Diseases Group of European Organization for Research and Treatment of Cancer (EORTC-IDG)
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean KlasterskyMartine Barette
Sep 28, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Helen InnesErnest Marshall
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael H CullenNeil M Steven
Jan 26, 2008·The Journal of Antimicrobial Chemotherapy·C CattaneoG Rossi
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda S EltingKenneth Rolston
Oct 22, 2008·Lancet·Longde WangMary Elizabeth Wilson
Jan 6, 2009·Lancet·Andreas HeddiniGöran Tomson
Feb 18, 2010·Lancet·Jiyao Wang
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roland A AmmannChristoph Aebi
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jyoti D PatelPatrick J Loehrer
Sep 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James A TalcottPaul A Godley
Jan 16, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher R FlowersScott D Ramsey
Jan 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Winfried V KernThierry Calandra
Dec 9, 2014·Anti-cancer Drugs·Lixian HeGuowang Yang
Citations
Jun 20, 2015·Leukemia & Lymphoma·Monica A Slavin, Karin A Thursky
Jun 17, 2015·Expert Opinion on Pharmacotherapy·Filippos KoinisAthanasios Kotsakis
May 22, 2016·Infectious Disease Clinics of North America·Donald M Dumford, Marion Skalweit
Nov 2, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·A JoncourBlandine Rammaert
Apr 15, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Samira M HamedWalid F Elkhatib
May 23, 2020·Infection and Drug Resistance·Effat Abbasi MontazeriSakineh Seyed-Mohammadi
Aug 18, 2018·Scientific Reports·Samira M HamedKhaled M A Aboshanab