Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus

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Massimiliano BianchiCharles A Marsden

Abstract

A number of studies suggest that stressful conditions can induce structural alterations in the hippocampus and that antidepressant drugs may prevent such deficits. In particular, the selective serotonin reuptake inhibitor (SSRI) fluoxetine was more effective in modulating different neuronal plasticity phenomena and related molecules in rat hippocampus. Cytoskeletal microtubule dynamics are fundamental to dendrites and axons remodeling, leading to the hypothesis that fluoxetine may affect the microtubular system. However, despite reports of stress-induced alterations in microtubule dynamics by different stressors, only few studies investigated the in vivo effects of antidepressants on microtubules in specific rat brain regions. The present study investigated the dose-related (1, 5, or 10 mg/kg i.p.) effects of acute and chronic (21 days) treatments with fluoxetine on the ratio of hippocampal alpha-tubulin isoforms which is thought to reflect microtubule dynamics. Western Blot analysis was used to quantify alpha-tubulin isoforms, high-performance liquid chromatography and fluorescence detection was used to measure ex vivo monoamine metabolism. The results showed that acute fluoxetine increased the stable forms acetylated and dety...Continue Reading

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Citations

Mar 21, 2013·Behavioural Brain Research·Estibaliz AmpueroFrancisco Javier Rubio
Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David J G WatsonKevin C F Fone
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Massimiliano Bianchi, Etienne-Emile Baulieu
Nov 30, 2010·The Journal of Biological Chemistry·Rahul H DavéMark M Rasenick
Dec 21, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Chiara PiubelliLucia Carboni
Jul 9, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Massimiliano BianchiCharles A Marsden
Oct 26, 2010·Journal of Neurochemistry·Vincent FournetMarie-Pascale Martres
Sep 22, 2012·Ageing Research Reviews·Ginger Tsz-Hin WongAndrew Chi-Kin Law
Sep 28, 2013·Physics of Life Reviews·Stuart Hameroff, Roger Penrose
Oct 19, 2016·Cytoskeleton·Francesca MarchisellaPatrik Hollos
Feb 22, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Harinder SinghMark M Rasenick
Jan 10, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Benita JinV Reggie Edgerton
Dec 17, 2020·Developmental Neurobiology·Marie-Jo MoutinAnnie Andrieux

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