Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies

British Journal of Clinical Pharmacology
Shan-Yan GaoYu-Hong Zhao

Abstract

To investigate the safety of fluoxetine use during pregnancy, and to better understand the relationship between maternal fluoxetine use during the first trimester and congenital malformations in infants. PubMed and Web of Science databases were systematically searched from inception to 21 March 2016. Additional studies were identified in a manual search of the reference lists. Two reviewers independently extracted data. A third reviewer checked the data. Estimates were pooled using a random-effects model to calculate the summarized relative ratios (RR) and 95% confidence intervals (CI). Among 1918 initially identified articles, 16 cohort studies were included. The offspring of pregnant women exposed to fluoxetine during the first trimester had a statistically increased risk of major malformations (RR = 1.18, 95% CI = 1.08-1.29), cardiovascular malformations (RR = 1.36, 95% CI = 1.17-1.59), septal defects (RR = 1.38, 95% CI = 1.19-1.61), and non-septal defects (RR = 1.39, 95% CI = 1.12-1.73) with low heterogeneity in infants. There were no significant observations of other system-specific malformations in the nervous system, eye, urogenital system, digestive system, respiratory system, or musculoskeletal system, respectively. Th...Continue Reading

References

Jun 1, 1978·Journal of Epidemiology and Community Health·J L KelseyM B Bracken
Dec 1, 1978·American Journal of Epidemiology·D U HimmelbergerE N cohen
Jun 25, 1971·Nature·E D Alberman, H Goldstein
Jun 1, 1993·Teratology·M S YavaroneJ M Lauder
May 5, 1993·JAMA : the Journal of the American Medical Association·A PastuszakC Woodland
Oct 3, 1996·The New England Journal of Medicine·C D ChambersK L Jones
Jan 23, 1997·The New England Journal of Medicine·I NulmanG Koren
May 1, 1997·Obstetrics and Gynecology·D J GoldsteinK L Sundell
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Aug 10, 1999·Current Opinion in Pediatrics·B G Kousseff
Aug 4, 2001·BMJ : British Medical Journal·J EvansJ Golding
May 3, 2003·The American Journal of Psychiatry·Victoria HendrickDesiree Haynes
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 9, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Youssef Sari, Feng C Zhou
Feb 18, 2004·European Journal of Clinical Pharmacology·D G HansenJ Kragstrup
Mar 31, 2004·Obstetrics and Gynecology·Heather A BennettThomas R Einarson
Jan 7, 2005·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Lori BonariGideon Koren
Mar 30, 2005·Expert Opinion on Drug Safety·Sanjog KalraAdrienne Einarson
Jul 2, 2005·Journal of Psychiatric Practice·L L AltshulerR W Ross
Jan 12, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bengt A J Källén, Petra Otterblad Olausson
May 12, 2007·BMJ : British Medical Journal·Veronica O'Keane, Michael S Marsh
Jun 6, 2007·American Journal of Obstetrics and Gynecology·William O CooperWayne A Ray
Dec 7, 2007·Journal of Perinatal Medicine·Jordan S Kase, Paul Visintainer
Feb 23, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Tim F OberlanderClyde Hertzman
Aug 30, 2008·British Journal of Clinical Pharmacology·Orna Diav-CitrinAsher Ornoy
Mar 27, 2009·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Adrienne EinarsonGideon Koren
Aug 20, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Paul MerlobGil Klinger
Dec 7, 2010·L'Encéphale·O Chatillon, C Even
Mar 8, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lyn ColvinCarol Bower
Jun 8, 2011·Obstetrics and Gynecology·Heli MalmAnnukka Ritvanen
Jan 5, 2012·Archives of Women's Mental Health·Deana B DavalosHope C Tregellas
Dec 6, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Q J WuY B Xiang
Apr 5, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Q J WuY B Xiang
May 10, 2013·The Journal of Clinical Psychiatry·Sophie GrigoriadisLori E Ross
May 11, 2013·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Lauren RigginGideon Koren

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Citations

Jul 7, 2017·British Journal of Clinical Pharmacology·Nancy Lutwak, Curt Dill
Jun 13, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erica L L Warkus, Yusuke Marikawa
Feb 23, 2020·Birth Defects Research·Robert M CabreraBogdan J Wlodarczyk
May 15, 2018·The Annals of Pharmacotherapy·Vanessa Alves-ConceiçãoDivaldo Pereira de Lyra-Jr
Apr 26, 2019·British Journal of Clinical Pharmacology·Li Wei, Adam Cohen
Jun 27, 2019·Pain Practice : the Official Journal of World Institute of Pain·Eleanor BlackApo Demirkol
Feb 8, 2020·Nature Reviews. Disease Primers·Stylianos E AntonarakisRoger H Reeves
Apr 26, 2019·British Journal of Clinical Pharmacology·Andrew J Webb
Dec 22, 2020·Frontiers in Behavioral Neuroscience·Lu BaiLong Wang
Dec 24, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Courtney De VriesElizabeth Roughead
Aug 14, 2021·Asian Journal of Psychiatry·Ritwik GhoshVijay Kumar
Aug 28, 2021·Neurology International·Amber N EdinoffAdam M Kaye
Dec 6, 2017·Fertility and Sterility·Carlos Hernandez-NietoBenjamin Sandler

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