Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Omar M E Abdel Salam

Abstract

The effect of the selective serotonin reuptake inhibitors, fluoxetine and sertraline on basal, secretagogues (histamine or bethanechol)- and distention-stimulated gastric acid secretion was investigated in the urethane-anaesthetised acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric contents with saline every 15 min. Fluoxetine (10 or 20 mg kg(-1), i.p.) produced a dose-dependent increase in basal gastric acid secretion. These stimulatory effects were abolished by vagotomy. Intraperitoneally administered sertraline also stimulated gastric acid secretion. The stimulatory effect of lower doses (5 mg kg(-1)) of sertraline was similar to that of the higher (30 mg kg(-1)) doses. The gastric secretory response to i.p. sertraline was long lasting (greater than 60 min), and blocked by vagotomy. Intraperitoneally administered fluoxetine (10 or 20 mg kg(-1)) or sertraline (5 mg kg(-1)) also increased gastric secretion induced by histamine, bethanechol or distention. The fluoxetine or sertraline stimulatory effects of histamine-induced acid secretion were abolished by vagotomy. Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in uretha...Continue Reading

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Citations

Apr 25, 2012·European Journal of Clinical Pharmacology·Franck MaschinoUNKNOWN French Association of Regional Pharmacovigilance Centers
Apr 4, 2015·Expert Opinion on Drug Safety·Janne Kaergaard Mortensen, Grethe Andersen
Jul 5, 2015·Gastrointestinal Endoscopy Clinics of North America·Thomas TiellemanByron Cryer
Sep 24, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomohisa TakahashiSoichiro Nomura
Oct 30, 2016·Trends in Neurosciences·Amar SarkarPhilip W J Burnet
Jan 29, 2019·The Journal of the American Osteopathic Association·Wei Cheng YuetMichael Jann
Jul 2, 2008·Biological & Pharmaceutical Bulletin·Takumi YamaguchiHiroaki Araki
Feb 3, 2019·Medical Sciences : Open Access Journal·Alper EvrenselMehmet Emin Ceylan
Oct 23, 2019·Heart, Lung & Circulation·George MawardiBrian A Houston
Nov 18, 2020·Current Treatment Options in Gastroenterology·Takeshi Kanno, Paul Moayyedi
Jun 29, 2021·Journal of Clinical Psychopharmacology·Maximilian GahrRené Zeiss
Jul 20, 2021·Cellular and Molecular Neurobiology·Qiang YueChang Zeng

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