PMID: 9416385Jan 7, 1998Paper

Fluoxetine-associated stomatitis

The Annals of Pharmacotherapy
V PalopI Martínez-Mir

Abstract

To describe two cases of stomatitis related to fluoxetine given for the treatment of depression that were detected in the hospital emergency department. Two women developed stomatitis after the intake of fluoxetine for the treatment of depression. One of the patients had six recurrent episodes of stomatitis without suspecting an association with fluoxetine. No other drugs were administered during these episodes. The second patient was treated concurrently with fluoxetine and bentazepam. In both patients the lesion improved upon discontinuation of fluoxetine, even though the second patient continued to take a different benzodiazepine. Stomatitis related to fluoxetine has not been previously reported in clinical trials or in the literature. According to the causal algorithm used by the Spanish Drug Surveillance Schemes, the first case constituted a defined adverse reaction and the second was probable. Our observations suggest that fluoxetine may be considered as a probable cause of stomatitis. The reporting of isolated cases of adverse drug reactions (ADRs) makes it possible to define the toxicity profile of recently marketed drugs such as selective serotonin-reuptake inhibitors, including fluoxetine. Emphasis is placed on the po...Continue Reading

References

Jul 1, 1995·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P Wolkenstein, J Revuz

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