Fluoxetine attenuates morphine-induced locomotion and blocks morphine-sensitization

European Journal of Pharmacology
T L Sills, P J Fletcher

Abstract

Repeated morphine treatments result in sensitization, an increase in the efficacy of morphine to stimulate locomotor activity. study examined the effects of increasing serotonin (5-hydroxytryptamine, 5-HT) transmission on morphine-sensitization. For five days rats were administered saline or 5.0 mg/kg fluoxetine prior to treatment with saline or 5.0 mg/kg morphine. Twenty-one days later, rats were tested for their locomotor response to 2.0 mg/kg morphine. Fluoxetine treatment attenuated the locomotor activating effect of acute morphine treatments and blocked the sensitized response to the morphine challenge. These results indicate that increased 5-HT transmission attenuates the locomotor stimulating effects of morphine and prevents the development of morphine-sensitization.

References

Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y G Ni, R Miledi

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Citations

Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·M Rodríguez-AriasJ Miñarro
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Peter OlaussonBo Söderpalm
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Jun 26, 2004·Annual Review of Neuroscience·Raul R GainetdinovMarc G Caron
Dec 6, 2005·Biological & Pharmaceutical Bulletin·Rong Jie ZhaoChae Ha Yang
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Apr 25, 2003·Alcoholism, Clinical and Experimental Research·Christina N Lessov, Tamara J Phillips
Jul 27, 2000·Annals of the New York Academy of Sciences·K A SevarinoT R Kosten
Jan 27, 2021·The American Journal of Drug and Alcohol Abuse·Benyamin KiashemshakiHossein Miladi-Gorji
Oct 13, 2017·Pharmacology, Biochemistry, and Behavior·María J VarelaJuan F Lopez-Gimenez
Apr 21, 2010·Pharmacology, Biochemistry, and Behavior·S Raz, B D Berger

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