Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex

Psychopharmacology
Frank P BymasterKenneth W Perry

Abstract

The selective serotonin uptake inhibitor (SSRI) fluoxetine has been shown to not only increase the extracellular concentrations of serotonin, but also dopamine and norepinephrine extracellular concentrations in rat prefrontal cortex. The effect of other SSRIs on monoamine concentrations in prefrontal cortex has not been thoroughly studied. The aim of this study was to compare the ability of five systemically administered selective serotonin uptake inhibitors to increase acutely the extracellular concentrations of serotonin, norepinephrine and dopamine in rat prefrontal cortex. The extracellular concentrations of monoamines were determined in the prefrontal cortex of conscious rats using the microdialysis technique. Fluoxetine, citalopram, fluvoxamine, paroxetine and sertraline similarly increased the extracellular concentrations of serotonin from 2- to 4-fold above baseline. However, only fluoxetine produced robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. Fluoxetine at the same dose blocked ex vivo binding to the serotonin transporter, but not the norepinephrine transporter, suggesting that the increase of catecholamines was not due to non-select...Continue Reading

Citations

Apr 2, 2009·Psychopharmacology·Atheir I AbbasBryan L Roth
Jun 1, 2006·Current Psychiatry Reports·Lesley M Arnold
Mar 10, 2012·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Tierney A Lorenz, Cindy M Meston
May 3, 2003·Life Sciences·Robert J Donati, Mark M Rasenick
May 6, 2003·Chemosphere·Bryan W BrooksDuane B Huggett
Jan 29, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea BariTrevor W Robbins
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tomi RantamäkiEero Castrén
Jan 24, 2013·Translational Psychiatry·R Kaddurah-DaoukO Fiehn
Aug 19, 2007·Journal of Asian Natural Products Research·Song LiMin-Wei Wang
May 23, 2012·Cerebral Cortex·Andrew R AbelaY Chudasama
Jul 18, 2002·Behavioural Pharmacology·D M BarrosI Izquierdo
Sep 9, 2005·Behavioural Pharmacology·J M WitkinG G Nomikos
Oct 3, 2006·International Clinical Psychopharmacology·David G S PerahiaJoel Raskin
Sep 1, 2007·Behavioural Pharmacology·Jessica A Valluzzi, KinHo Chan
Sep 10, 2009·International Clinical Psychopharmacology·Alexandra Schosser, Siegfried Kasper
Feb 14, 2006·Science·Samuel R ChamberlainBarbara J Sahakian
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Peter R Bieck, William Z Potter
Mar 3, 2005·Neuropsychobiology·Patrizia BlardiPaolo Castrogiovanni
Nov 20, 2013·Philosophy, Ethics, and Humanities in Medicine : PEHM·Bruno FalissardAnne Fagot-Largeault
Jun 10, 2006·Arthritis Research & Therapy·Lesley M Arnold
Mar 1, 2014·Brain : a Journal of Neurology·Zheng YeJames B Rowe
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yasin TemelTrevor Sharp
Jul 22, 2014·ISRN Pharmacology·Kennedy K E KukuiaDonatus W Adongo
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·John F CryanIrwin Lucki
Apr 5, 2014·Psychopharmacology·Mari S Golub, Casey E Hogrefe
Sep 16, 2008·Journal of Women's Health·Christine N HuynhLaura A Morgan
Apr 1, 2003·Expert Opinion on Investigational Drugs·Frank P BymasterPierre V Tran
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·Pierre Blier
Oct 28, 2008·Stress : the International Journal on the Biology of Stress·Christopher A LowryCliff H Summers
Apr 18, 2014·Expert Opinion on Drug Discovery·Laura Perez-CaballeroEsther Berrocoso

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