Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins

Brain Research
Q LiL D Van de Kar

Abstract

The time course of fluoxetine-induced supersensitivity of hypothalamic 5-HT2A/2C receptors was examined. Daily injections of fluoxetine (7 or 14 days) significantly increased agonist ([125I]DOI)-labeled high-affinity-state 5-HT2A/2C receptors in the hypothalamus, but not frontal cortex. No change was observed in the density of [3H]ketanscrin-labeled 5-HT2A receptors in either brain region. The levels of Gq- and G11- proteins in the hypothalamus and cortex were not altered by fluoxetine. These results suggest that fluoxetine gradually increases the G-protein coupling of 5-HT2A/2C receptors without altering the levels of Gq- or G11-proteins.

References

Aug 15, 1995·European Journal of Pharmacology·N TilakaratneE Friedman

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Citations

Jun 24, 1999·The Journal of Comparative Neurology·V Cornea-HébertL Descarries
Mar 26, 2003·Life Sciences·Dirk Van OekelenJosée E Leysen
Sep 30, 1999·Life Sciences·D K Raap, L D Van de Kar
Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·J L FrankC H Olson
Jun 29, 2002·Nuclear Medicine and Biology·Yolanda Zea-PonceMarc Laruelle
Jan 21, 2006·Brain Research·Lynda UphouseBruce Grossie
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Jul 21, 2009·Respiratory Physiology & Neurobiology·C RealP Escourrou
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Aug 12, 2010·Behavioural Pharmacology·Erika Estrada-CamarenaAlonso Fernández-Guasti
Jul 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erika Estrada-CamarenaCarolina López-Rubalcava
Apr 6, 2004·The Journal of Pharmacology and Experimental Therapeutics·Yahong ZhangLouis D Van de Kar
Jul 25, 2007·The Journal of Pharmacology and Experimental Therapeutics·Ju ShiNancy A Muma

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