Fluoxetine increases cerebral white matter NAA/Cr ratio in patients with multiple sclerosis

Neuroscience Letters
Jop P MostertJacques De Keyser

Abstract

Axonal degeneration in multiple sclerosis (MS) may be caused by mitochondrial dysfunction and is associated with decreased levels of N-acetylaspartate (NAA) as measured with 1H-magnetic resonance spectroscopy (MRS). Fluoxetine stimulates astrocytic glycogenolysis, which serves as an energy source for axons. Eleven patients with MS received fluoxetine orally 20 mg a day during the first week, and 40 mg a day during the second week. The mean NAA/Creatine ratio in cerebral white matter of the MS patients increased from 1.77 at baseline to 1.84 at the end of the second week (p=0.007). These findings show evidence for a reversible axonal dysfunction in patients with MS and provide a rationale for investigating whether fluoxetine has neuroprotective effects in MS.

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Citations

Jun 24, 2010·Biological Psychiatry·Meredith A ReidAdrienne C Lahti
Nov 26, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Charalampos I MitsonisDemetrios C Vassilopoulos
Oct 16, 2007·Journal of the Neurological Sciences·Jacques De KeyserMarcus W Koch
May 17, 2008·CNS Neuroscience & Therapeutics·Jop P MostertJacques De Keyser
May 24, 2016·Pharmacoepidemiology and Drug Safety·Tingting ZhangHelen Tremlett
Nov 4, 2015·Autism Research : Official Journal of the International Society for Autism Research·Lauren E LiberoRajesh K Kana
Sep 2, 2008·Expert Review of Neurotherapeutics·Albert Lo
Jan 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Melissa CambronJacques De Keyser
Apr 12, 2018·Expert Opinion on Emerging Drugs·Ram Narendra NarayanOlaf Stüve
Apr 5, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Lisa B GrechRobert Hester
Apr 20, 2014·Brain Structure & Function·Izuchukwu D UgwuThomas Frodl
Jun 21, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Jeremy ChatawayRobert J Fox
May 26, 2017·Multiple Sclerosis International·Sandipan BhattacharjeeTerri Warholak
Aug 29, 2020·International Journal of Molecular Sciences·Petra HnilicováEma Kantorová
Jun 4, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A A SviridovaA N Boyko
Nov 29, 2020·Glia·Sofia Pereira das NevesFernanda Marques
Mar 5, 2021·Brain, Behavior, and Immunity·Tiziana CarandiniMarco Bozzali
Mar 24, 2021·Multiple Sclerosis and Related Disorders·Mikhail MelnikovAlexey Boykо

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