Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment

Neuroscience
G de FoubertT S Zetterström

Abstract

Recent studies indicate that brain-derived neurotrophic factor (BDNF) may be implicated in the clinical action of antidepressant drugs. Repeated (2-3 weeks) administration of antidepressant drugs increases BDNF gene expression. The onset of this response as well as concomitant effects on the corresponding BDNF protein is however, unclear. The present study investigated the effects of acute and chronic administration of the selective serotonin reuptake inhibitor, fluoxetine (10mg/kg p.o.), upon regional rat brain levels of BDNF mRNA and protein expression. To improve the clinical significance of the study, fluoxetine was administered orally and mRNA and protein levels were determined ex vivo using the techniques of in situ hybridisation histochemistry and immunocytochemistry respectively. Direct measurement of BDNF protein was also carried out using enzyme-linked immunosorbent assay (ELISA). Four days of once daily oral administration of fluoxetine induced decreases in BDNF mRNA (hippocampus, medial habenular and paraventricular thalamic nuclei). Whilst 7 days of treatment showed a non-significant increase in BDNF mRNA, there were marked and region-specific increases following 14 days of treatment. BDNF protein levels remained u...Continue Reading

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Citations

Dec 17, 2010·Psychopharmacology·Valerio RicciFrancesco Angelucci
Jan 3, 2012·Rheumatology International·Boya NugrahaChristoph Gutenbrunner
Aug 6, 2010·Journal of Neural Transmission·Jucélia J FortunatoJoão Quevedo
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