Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression

Acta Pharmacologica Sinica
Shu-Juan PanJing Xiong

Abstract

Depressive disorders are frequently managed with long-term use of antidepressant medication. Fluoxetine (FLX) is the first selective serotonin reuptake inhibitor to be widely available for the treatment of depression. The present study focuses on the effects and mechanisms of the lipid metabolism abnormalities caused by FLX in patients and in a mouse model of depression. Depression severity was assessed by the Hamilton Depression Scale (HAMD). Triglyceride (TG), cholesterol (TC) and low-density lipoprotein (LDL) serum levels were assessed in 28 patients with depression, aged 31.2±3.3 years, treated with FLX (20 to 60 mg/day) for 8 weeks. Meanwhile, the serum levels of other lipid metabolism-related parameters, such as high-density lipoprotein (HDL), apolipoprotein A1 (APOA1) and apolipoprotein B (ApoB), were also determined. The infiuence of FLX on the hepatic lipid profile and hepatic gene expression of both lipogenic and lipolytic enzymes was evaluated in a mouse model of depression treated with FLX (10 mg·kg-1·d-1, ip) for 4 weeks. We showed that the serum TG, TC and LDL levels were significantly increased in patients with depression after FLX treatment. The elevation in serum TG levels in the patients was not affected by ge...Continue Reading

References

Jan 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·M O'KaneJ K Wales
Feb 11, 2000·The Annals of Pharmacotherapy·G D Garrison, G M Levin
May 25, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Craig H. MallinckrodtPierre V. Tran
Sep 11, 2004·Journal of the American College of Cardiology·Scott M GrundyUNKNOWN Coordinating Committee of the National Cholesterol Education Program
Feb 9, 2005·Archives of General Psychiatry·Michael R LiebowitzDennis Munjack
Aug 27, 2005·Nature Reviews. Drug Discovery·David T WongFrank P Bymaster
Dec 30, 2006·The Journal of Clinical Psychiatry·Maria B RaederVidar M Steen
Dec 17, 2008·Journal of Psychopharmacology·J M Le MelledoJ Perez-Parada
Aug 5, 2009·Biochimica Et Biophysica Acta·Kerry W S KoRichard Lehner
Apr 20, 2010·International Clinical Psychopharmacology·Amy H FarabaughGeorge I Papakostas
Nov 16, 2010·Journal of Affective Disorders·Kristen DelMastroPerry F Renshaw
Mar 29, 2011·Expert Review of Cardiovascular Therapy·John Richard, Ildiko Lingvay
May 3, 2011·Trends in Endocrinology and Metabolism : TEM·Ariel D Quiroga, Richard Lehner
May 4, 2012·Current Topics in Behavioral Neurosciences·Patricia A ZunszainCarmine M Pariante
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Esmaeil Shahsavand AnanlooMajid Sadeghi
Aug 8, 2014·The International Journal of Biochemistry & Cell Biology·Jing XiongJian Yang
May 22, 2016·The International Journal of Neuropsychopharmacology·Ren-Hong DuGang Hu
Jun 12, 2016·The Journal of Endocrinology·Xuemei TangLixia Gan
Jun 2, 2017·Nöro Psikiyatri Arşivi·Özlem Olguner EkerHatice Doğan
Nov 1, 2017·Journal of Neuroinflammation·Wen-Jun SuChun-Lei Jiang

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Citations

Jun 30, 2019·Journal of Leukocyte Biology·Kehong ZhangXinchun Chen
Jul 23, 2020·Arquivos brasileiros de cardiologia·Etiene Oliveira da Silva FittipaldiMaria Teresa Jansen de Almeida Catanho
Nov 13, 2020·Journal of Applied Toxicology : JAT·Shuanghui LuHuidi Jiang
Oct 28, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tao YaoGaohua Wang
Jan 6, 2021·Archives of Toxicology·Nevena Todorović VukotićSnežana B Pajović
Jan 31, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yuan HuPing Liu
Jun 3, 2021·Food & Function·Haining YuWeiguang Shan
Jul 30, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Rui YangBi-Lian Liu
Aug 8, 2021·International Journal of Molecular Sciences·Anna TkachevPhilipp Khaitovich
Feb 2, 2021·Canadian Journal of Physiology and Pharmacology·Ahmed Ayyash, Alison C Holloway
Aug 20, 2021·Frontiers in Psychology·Hua LuoYu Ren
Dec 16, 2021·Endocrinology and Metabolism·Jiwon ParkChang-Myung Oh

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Methods Mentioned

BETA
protein assay

Software Mentioned

ImageJ
SPSS

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