Fluoxetine inhibits cortical spreading depression in weaned and adult rats suckled under favorable and unfavorable lactation conditions

Experimental Neurology
Angela Amâncio dos SantosRubem C A Guedes

Abstract

Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-injected (n = 24) or "ingenuous" (n = 16) controls, fluoxetine dose-dependently reduced (P < 0.05) SD-velocities in the young rats by 4, 6, 16 and 15%, respectively, and in adult rats by 13%. In another experiment (26 adult rats), topical cortical application of fluoxetine (5 and 10 mg/ml solutions over the intact dura-mater for 10 min; n = 12 and 14, respectively) dose-dependently reduced SD-velocity (7.6% and 43.3% maximal reductions; P < 0.05). SD-propagation was blocked in 4 out of the 14 W-rats topically treated with the highest fluoxetine concentration (10 mg/ml). This topical fluoxetine effect was reverted after flushing the treated region with saline. In additional, 58 early-malnourished rats, fluoxetine applied during the suckling period (10 mg/kg/day, s.c.) and topically (10 mg/ml) also reduced (P < 0.05) SD-velocities by 18 and 22% for the systemic treatment (young and adult animals, respectively) and by 2...Continue Reading

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Citations

Dec 17, 2010·Journal of Neural Transmission·J TajtiL Vécsei
Sep 9, 2009·Cephalalgia : an International Journal of Headache·C Ayata
Jan 1, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cássia Borges LimaRubem Carlos Araujo Guedes
Apr 29, 2010·Nutritional Neuroscience·Juliana Maria Carrazzone BorbaRubem Carlos Araújo Guedes
Nov 3, 2010·European Journal of Pharmacology·Márlison José Lima de AguiarRubem Carlos Araújo Guedes
Oct 28, 2010·Neurobiology of Disease·Volodymyr Borysovych BogdanovJean Schoenen
Jul 7, 2009·Experimental Neurology·Ana Paula Barbosa do AmaralRubem Carlos Araújo Guedes
May 23, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Angélica da Silva TenórioRubem Carlos Araújo Guedes
Jun 11, 2008·Alcoholism, Clinical and Experimental Research·Ricardo Abadie-GuedesRanilson de Souza Bezerra
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Ricardo Abadie-GuedesRanilson S Bezerra
Jan 17, 2013·Nutritional Neuroscience·Rubem Carlos Araújo GuedesElian da Silva Francisco
Jul 16, 2011·Nutritional Neuroscience·Heloisa Mirelle Costa MonteiroRubem Carlos Araújo Guedes
May 16, 2012·Nutritional Neuroscience·R C A GuedesRanilson de Souza Bezerra
Nov 21, 2007·Nutritional Neuroscience·Katia Karina Do Monte-SilvaRubem Carlos Araújo Guedes
Feb 26, 2013·Nutritional Neuroscience·Paula Catirina Pereira da Silva GermanoRubem Carlos Araújo Guedes
May 26, 2015·European Journal of Pharmacology·Heloísa Mirelle Costa MonteiroÂngela Amâncio-Dos-Santos
Mar 19, 2013·European Journal of Pharmacology·Angela Amancio-Dos-SantosRubem Carlos Araújo Guedes
Jan 23, 2015·Cephalalgia : an International Journal of Headache·Enriqueta Muñoz-IslasCarlos M Villalón
Apr 21, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna KlassEdgar Santos
Nov 11, 2017·Nutritional Neuroscience·Suênia Marcele Vitor-de-LimaRubem Carlos Araújo Guedes
Jun 2, 2018·Nutritional Neuroscience·Heloísa Mirelle Costa MonteiroAngela Amancio-Dos-Santos
Mar 1, 2012·Expert Review of Neurotherapeutics·Katharina Eikermann-HaerterCenk Ayata
Jun 25, 2021·Expert Review of Neurotherapeutics·Doga VuralliHayrunnisa Bolay

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