Fluoxetine modulates the circadian biological clock via phase advances of suprachiasmatic nucleus neuronal firing

Biological Psychiatry
Jeffrey SprouseLinda Reynolds

Abstract

The documented ability of serotonin (5-HT) to directly modulate circadian rhythms prompted interest in a similar role for therapeutic agents that readily enhance 5-HT neurotransmission, namely the selective serotonin reuptake inhibitors (SSRIs). Extracellular recordings of unit firing of suprachiasmatic nucleus (SCN) neurons maintained in slice culture enabled determinations of circadian rhythmicity. Shifts in the peak of activity were determined during the next circadian cycle following drug exposure. Fluoxetine (10 microm, 60 minutes incubation) produced robust phase advances only in the presence of L-tryptophan (.5 microm), added to maintain serotonergic tone. Actions of SSRIs at the level of the circadian biological clock add to the list of pharmacological effects for this drug class and encourage speculation as to their importance clinically.

References

Aug 1, 1978·The Journal of Comparative Neurology·R Y MooreB E Jones
Jan 1, 1991·Chronobiology International·H NagayamaT Tashiro
Mar 1, 1995·Journal of Biological Rhythms·J D GlassM A Rea
Apr 9, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·W E Bunney, B G Bunney
Apr 16, 2003·Journal of Biological Rhythms·Michael C AntleRalph E Mistlberger
Mar 8, 2005·Trends in Neurosciences·Michael C Antle, Rae Silver
Jul 6, 2005·Neuron·Quan YuanAmita Sehgal
Jul 28, 2005·Psychological Medicine·Anna Wirz-JusticeJoseph C Wu

❮ Previous
Next ❯

Citations

Oct 15, 2013·Trends in Pharmacological Sciences·Analyne M Schroeder, Christopher S Colwell
Jan 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Virginia SoriaMikel Urretavizcaya
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·C A McClung
Feb 14, 2007·Journal of Circadian Rhythms·Sevag A KaladchibachiArmen S Manoukian
Mar 3, 2010·PloS One·Catharina LavebrattMartin Schalling
Oct 12, 2012·PloS One·Deborah R BooneHelen L Hellmich
Jan 26, 2013·Pharmacology & Therapeutics·Laurence LanfumeyMichel Hamon
Nov 1, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Philippe Courtet, Emilie Olié
Aug 13, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Colleen A McClung
Aug 22, 2009·Brain Research Reviews·Alan M Rosenwasser
Jul 30, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Palmiero Monteleone, Mario Maj
Mar 31, 2007·Pharmacology & Therapeutics·Colleen A McClung
May 22, 2009·Journal of Neurochemistry·Marc CuestaEtienne Challet
Aug 18, 2010·Bipolar Disorders·Greg Murray, Allison Harvey
Nov 10, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Ping HuaTianxia Wu
Sep 5, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nicole Edgar, Colleen A McClung
Dec 18, 2013·Annals of the New York Academy of Sciences·Ellen FrankBrant P Hasler
May 20, 2015·Journal of Neural Transmission·Julian Hellmann-RegenGolo Kronenberg
May 18, 2010·Clinical Psychology Review·Allison G HarveyAdriane Soehner
Jun 27, 2015·Current Psychiatry Reports·Sara Dallaspezia, Francesco Benedetti
May 6, 2016·Frontiers in Psychiatry·Angela R OzburnColleen A McClung
Aug 10, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Palmiero MonteleoneMario Maj
Aug 30, 2011·Neuropharmacology·Noga Kronfeld-Schor, Haim Einat
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Blynn G Bunney, William E Bunney
Nov 8, 2018·The European Journal of Neuroscience·Kyle D KetchesinColleen A McClung
Nov 22, 2018·Nature Reviews. Neuroscience·Ryan W Logan, Colleen A McClung
Feb 24, 2019·Health Promotion International·Tamara MackeanFrances Baum
Sep 14, 2018·Journal of Circadian Rhythms·Hiroshi KawaiAtsushi Mitsumoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.