Fluoxetine or Sox2 reactivate proliferation-defective stem and progenitor cells of the adult and aged dentate gyrus

Neuropharmacology
Laura MicheliFelice Tirone

Abstract

The dentate gyrus of the hippocampus and the subventricular zone are neurogenic niches where the production of new neurons from glia-like stem cells continues throughout adult life. It is not clear whether the pool of stem cells is fated to be exhausted or is conserved until old age. We observed that the antiproliferative gene Btg1 maintains the quiescence of stem cells, and its ablation causes an increase of stem/progenitor cells proliferation in neonatal mice followed by progressive loss of proliferation during adulthood. Fluoxetine is an antidepressant, which exerts a powerful neurogenic effect on dentate gyrus progenitor cells, but is ineffective on stem cells. Here we show that adult dentate gyrus stem cells in the Btg1 knockout mice, with reduced self-renewal and proliferative capability, can be reactivated by fluoxetine, which increases their number greatly above the level of control or fluoxetine-treated wild-type mice. The increase of mitotic index above wild-type in Btg1 knockout fluoxetine-treated stem cells indicates that fluoxetine forces quiescent stem cells to enter the cycle. Stem cell proliferation undergoes continuous reactivation until fluoxetine is administered. Remarkably, fluoxetine reactivates proliferati...Continue Reading

References

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·P R Rapp, M Gallagher
Aug 28, 1999·The Journal of Comparative Neurology·N B Hastings, E Gould
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Jul 16, 2003·The European Journal of Neuroscience·J L Bizon, M Gallagher
Nov 19, 2003·The Journal of Comparative Neurology·Golo KronenbergGerd Kempermann
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Sep 24, 2004·Neuroscience Letters·Mila Komitova, Peter S Eriksson
Jun 15, 2005·Neurobiology of Aging·M F MontaronD N Abrous
Jul 23, 2005·The International Journal of Neuropsychopharmacology·Raffaella MolteniMarco Andrea Riva
Sep 20, 2005·Experimental Neurology·Sebastian JessbergerGerd Kempermann
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henriette van PraagFred H Gage
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunmei ZhaoFred H Gage
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Juan M EncinasGrigori Enikolopov
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing-Wen WangRené Hen
Jul 1, 2008·Nature Neuroscience·Sebastian JessbergerFred H Gage
Sep 16, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michelle C CarlsonBrenda L Plassman
Oct 10, 2008·PLoS Biology·Stefano Farioli-VecchioliFelice Tirone
Jan 14, 2009·Molecular Psychiatry·S Couillard-DespresL Aigner
Mar 21, 2009·Development, Growth & Differentiation·Itaru ImayoshiRyoichiro Kageyama
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oliver EhmD Chichung Lie
Apr 26, 2011·Frontiers in Physiology·Eumorphia RemboutsikaRobin Lovell-Badge
Dec 31, 2011·Frontiers in Neuroscience·Hamid R Noori, Casimir A Fornal
Sep 13, 2012·Frontiers in Neuroscience·Stefano Farioli-VecchioliFelice Tirone

❮ Previous
Next ❯

Citations

Feb 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giorgio D'AndreaFelice Tirone
Feb 23, 2019·Frontiers in Cellular Neuroscience·Laura MicheliFelice Tirone
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Tomomi SatoHiroshi Handa
Jun 5, 2021·Scientific Reports·Brenna HouriganQiumin Tan
Nov 7, 2020·Journal of Experimental & Clinical Cancer Research : CR·Qiang TangMaojun Di

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.