Fluoxetine treatment and testosterone levels

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
Stewart BellTim Haifley

Abstract

Two published case studies have reported SRI/SNRI-associated low testosterone levels. Apathy and low testosterone, observed during venlafaxine treatment in one report, both resolved upon venlafaxine discontinuation. No studies have investigated the effect of chronic SRI treatment on human testosterone levels. As decreased testosterone has several negative health effects, we conducted a pilot study investigating the effect of fluoxetine treatment on testosterone levels. Fourteen depressive disorder patients in good health (BDI = 15) were studied. In addition, 4 non-depressed patients were studied. Testosterone levels were drawn, and an apathy questionnaire (under development, not yet validated) was administered at intake. Fluoxetine was provided (10 mg/day for 7 days then 20 mg/day). To measure outcome, a follow-up testosterone level was drawn after 1 month's treatment. Eleven depressed, and 3 non-depressed, patients completed the study. While there were large differences-both increases and decreases-in some individuals' testosterone levels after fluoxetine treatment, for the study population as a whole, there was no relationship (depressed patients, p = 0.4; non-depressed patients, p 0.3) between fluoxetine treatment and testos...Continue Reading

Citations

Mar 20, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Fikret ErdemirErkan Sogut
Feb 21, 2014·International Journal of Psychiatry in Medicine·Hisashi MatsuzakaHeii Arai
Mar 8, 2021·European Journal of Pharmacology·Pavlina PavlidiChristina Dalla
Jun 12, 2009·Fertility and Sterility·Cigdem TanrikutPeter N Schlegel

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