Fluoxetine uses in nociceptive pain management: a promising adjuvant to opioid analgesics

Fundamental & Clinical Pharmacology
Mostafa M HamdyAhmed Barakat

Abstract

Fluoxetine, a commonly prescribed antidepressant, use in nociceptive pain management represents one of the unsettled issues of fluoxetine therapeutics. By reviewing the literature about fluoxetine's possible roles in this setting, those could be solitary antinociceptive effect, enhancement of acute morphine analgesia, blocking morphine tolerance development, and blocking dependence development and associated abstinence syndrome. In this study, we examined those four alleged roles of fluoxetine. Moreover, as effective alleviation of morphine tolerance, dependence, and abstinence syndrome represents one of the most challenging medical needs, we biochemically analyzed fluoxetine effect on these phenomena. Fluoxetine (10 mg/kg, IP) was examined in hot plate test for assessment of possible analgesic activity and enhancement of morphine acute analgesia (1 and 5 mg/kg, SC). Repeated morphine (5 mg/kg, SC) administration for 9 days developed tolerance and dependence; fluoxetine was co-administered to evaluate its potential to modulate these processes. We also determined concomitant changes in neurotransmitters (glutamate and noradrenaline), inflammatory status, and prooxidant-antioxidant balance. Our results indicated that fluoxetine d...Continue Reading

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Citations

Oct 26, 2018·Fundamental & Clinical Pharmacology·Marzieh KhademiZahra Taghipour
Mar 11, 2020·Frontiers in Pharmacology·Xian-Si ZengJin-Jing Jia
Jun 24, 2020·Peptides·Richard J Bodnar
Mar 13, 2019·Neuropharmacology·Christopher W CunninghamStephanie U Vold
Aug 28, 2021·Neurology International·Amber N EdinoffAdam M Kaye

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