Fluoxetine vs. propranolol in the treatment of vasovagal syncope: a prospective, randomized, placebo-controlled study

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
George N TheodorakisDimitrios Th Kremastinos

Abstract

To compare the therapeutic efficacy of placebo, propranolol, and fluoxetine in patients with vasovagal syncope (VVS). Ninety-six consecutive patients with VVS were randomized to treatment with placebo, propranolol, or fluoxetine and followed-up for 6 months. Before and during treatment, they reported their syncopal and presyncopal episodes and graded their well-being, expressed as the general evaluation of life, general activities, and everyday activities (each scaled from 1 = very good to 5 = very bad). Two patients refused follow-up. Among the remaining 94, no difference between groups was observed regarding the distribution of time of vasovagal events (syncopes or presyncopes) during follow-up (log-rank test). No difference was also observed when syncopes and presyncopes were assessed separately. Eighteen patients discontinued therapy. Among the remaining 76 ('on-treatment' analysis), the mean time to a vasovagal episode (syncope or presyncope) was significantly longer in the fluoxetine group when compared with the two other groups (log-rank test, P < 0.05). A significant difference in favour of fluoxetine was also observed regarding presyncopes. The difference between groups regarding the syncope-free period was not signifi...Continue Reading

References

Jan 1, 1991·Journal of Clinical Epidemiology·M LinzerW B Brooks
Nov 1, 1995·Journal of the American College of Cardiology·M M CoxR J Myerburg
Aug 1, 1994·Journal of the American College of Cardiology·B P GrubbP Brewster
Dec 1, 1996·Journal of Cardiovascular Electrophysiology·A NataleJ Sra
Sep 14, 1999·Circulation·D G BendittN Samniah
Nov 24, 1999·The American Journal of Cardiology·B P Grubb
Jul 18, 2000·Journal of the American College of Cardiology·G N TheodorakisD T Kremastinos
Sep 12, 2001·Circulation·A MoyaUNKNOWN International Study on Syncope of Uncertain Etiology (ISSUE) Investigators
Dec 12, 2001·Journal of the American College of Cardiology·R S SheldonS J Connolly
Nov 7, 2002·Pacing and Clinical Electrophysiology : PACE·Tony ReybrouckHugo Ector
Mar 27, 2003·European Heart Journal·G N TheodorakisD Th Kremastinos
Jan 1, 1997·European Psychiatry : the Journal of the Association of European Psychiatrists·E AngelopoulosC Stefanis

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Citations

Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Luciana Armaganijan, Carlos A Morillo
Jun 30, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jose Carlos M PachonTomas Guilhermo P Santillana
Jul 6, 2014·Autonomic Neuroscience : Basic & Clinical·Samuel T Coffin, Satish R Raj
May 7, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jacobus J C M RommeJohannes B Reitsma
Jul 19, 2012·Nature Reviews. Cardiology·Richard SuttonDavid G Benditt
Aug 22, 2008·Current Cardiology Reports·Vikas Kuriachan, Robert S Sheldon
Jan 11, 2007·Current Sports Medicine Reports·Chris A Klenck
Nov 26, 2013·Pediatric Clinics of North America·Thomas A Pilcher, Elizabeth V Saarel
Mar 12, 2013·Progress in Cardiovascular Diseases·Satish R Raj, Samuel T Coffin
Mar 12, 2013·Progress in Cardiovascular Diseases·Angel MoyaJordi Perez-Rodon
Dec 12, 2012·Cardiology Clinics·Juan C GuzmanCarlos A Morillo
Jun 1, 2012·Cardiac Electrophysiology Clinics·Troy Rhodes, Raul Weiss
Nov 6, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vikas KuriachanMichael Platonov
Sep 3, 2010·Journal of Cardiovascular Electrophysiology·Lin Yee Chen, David G Benditt
Dec 24, 2014·Expert Opinion on Pharmacotherapy·John William Schleifer, Win-Kuang Shen
Jun 28, 2015·Cardiology Clinics·Angel Moya
Feb 12, 2008·Journal of the American College of Cardiology·Maw Pin Tan, Steve W Parry
May 26, 2012·International Journal of Cardiology·Ankur VyasBrian Olshansky
Mar 10, 2016·Expert Review of Cardiovascular Therapy·Andrea K Y Lee, Andrew D Krahn
Oct 6, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Panayota FlevariJohn Lekakis
Dec 17, 2010·World Journal of Cardiology·Muhammet Ali AydinStephan Willems
Nov 30, 2018·Pacing and Clinical Electrophysiology : PACE·Jessica NgSatish R Raj
Aug 18, 2017·American Journal of Therapeutics·Amer N KadriNazih N Kadri
Jul 13, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Simone RomanoPietro Minuz
May 8, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Alan GarciaJorge Gomez-Flores
Oct 7, 2011·The Cochrane Database of Systematic Reviews·Jacobus Jcm RommeNynke Van Dijk
Dec 19, 2019·Frontiers in Cardiovascular Medicine·Robert S Sheldon, Roopinder K Sandhu
Sep 3, 2021·Autonomic Neuroscience : Basic & Clinical·Robert S Sheldon, Brenda Gerull
Aug 8, 2012·Pediatrics·Mark WalshRichard J Czosek

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