PMID: 8598370Mar 1, 1996Paper

Flutamide-induced liver toxicity including fatal hepatic necrosis

International Journal of Radiation Oncology, Biology, Physics
R L CrownoverK K Fu

Abstract

To describe hepatic injuries in three patients who received flutamide prior to and during radiation treatment to make radiation oncologists aware of the need for careful monitoring of liver function during use of this drug. The records of three patients who developed abnormal liver function tests while undergoing total androgen suppression (TAS), as well as the literature concerning flutamide toxicity were reviewed and summarized. Three of 34 patients treated with a TAS regimen incorporating flutamide developed significant hepatic abnormalities: elevated transaminases [2] and fatal hepatic necrosis [1]. Following the discontinuation of flutamide, two patients recovered fully. Unfortunately, the third patient's hepatic function continued to deteriorate, which culminated in his death. Transient elevations in serum transaminases, which do not exceed four times the upper limits of normal, are common and apparently without clinical significance. Unfortunately, idiosyncratic serious and/or fatal liver damage can occur. Significant liver toxicity may be obviated by monitoring of liver function tests (LFT) early in the course of flutamide therapy. The incidence of hepatic toxicity associated with flutamide may be higher than previously...Continue Reading

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Citations

Jul 31, 1999·Fertility and Sterility·L Falsetti, A Gambera
Apr 2, 2003·Urology·Douglas ScherrUNKNOWN National Comprehensive Cancer Network
Dec 18, 2004·Urologia Internationalis·Zebron TholeAgustin Hidalgo
Nov 13, 2001·American Journal of Clinical Dermatology·L FalsettiL Legrenzi
Nov 28, 2013·The Veterinary Clinics of North America. Exotic Animal Practice·Sue ChenErin Culpepper
Jan 29, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marieke TeppnerAxel Pähler
Aug 29, 2007·Clinics in Liver Disease·Edmundo A Rodriguez-Frias, William M Lee
Nov 25, 2005·International Urology and Nephrology·D PapaioannidesD Orphanidou
Apr 24, 1999·Human & Experimental Toxicology·M CetinK Unlühizarci

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