Flutamide-induced toxic hepatitis. Potential utility of ursodeoxycholic acid administration in toxic hepatitis

Digestive Diseases and Sciences
C CicognaniL Barbara

Abstract

Flutamide is a nonsteroidal antiandrogen commonly used in the treatment of prostate cancer. Hepatic toxicity associated with flutamide has been reported with an incidence from less than 1% to about 5%. Ursodeoxycholic acid (UDCA), a hydrophilic bile acid, has been widely used in the treatment of cholesterol gallstones and of several liver diseases, but few data are now available concerning its use in the management of drug-induced hepatitis. The case of a patient who presented severe hepatitis with jaundice following use of flutamide is reported. UDCA treatment was started on admission and, contemporaneously, flutamide was withdrawn. Clinical and biochemical improvement was progressively observed, and the patient was discharged six weeks after the admission. Since fatal flutamide-related hepatitis has been reported, monitoring of serum liver tests is advocated during flutamide administration, and the effectiveness of UDCA in the treatment of drug-induced hepatotoxicity requires further study.

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Citations

Nov 15, 2011·Archives of Toxicology·Mohammad Monir TawfeeqKunitoshi Mitsumori
Nov 25, 2005·International Urology and Nephrology·D PapaioannidesD Orphanidou
Apr 26, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Munekado KojimaTsuneharu Miki
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Aug 29, 2007·Clinics in Liver Disease·Edmundo A Rodriguez-Frias, William M Lee

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