Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity

Human Reproduction
Lourdes Ibáñez, Francis de Zegher

Abstract

Low-dose flutamide-metformin has been developed as a background therapy for non-obese adolescents and young women with hyperinsulinaemic hyperandrogenism, a variant of polycystic ovary syndrome (PCOS). We verified whether the lipolytic efficacy of flutamide-metformin in women with PCOS is enhanced by giving an oral contraceptive (OC) co-therapy that contains drospirenone, instead of gestodene, as progestin. An open-labelled study was carried out in which non-obese women with PCOS (n = 29; age approximately 20 years), who had been on a combination of flutamide (62.5 mg/day), metformin (850 mg/day) and ethinylestradiol-gestodene for 8-15 months, were randomized for replacement of the gestodene OC by a drospirenone OC. Assessments of endocrine-metabolic state and body composition (by dual-energy X-ray absorptiometry) were performed at randomization and after 6 months. The switch to drospirenone OC was accompanied by a reduction of total and abdominal fat (mean -0.8 and -0.5 kg) and by an increment of lean body mass (+0.6 kg; all P < 0.01), so that body adiposity was strikingly reduced without changing body weight. In non-obese women with PCOS, low-dose flutamide-metformin reduces total and abdominal fat excess more effectively if ...Continue Reading

Citations

Nov 17, 2007·Current Opinion in Obstetrics & Gynecology·Roger Hart
Dec 20, 2012·American Journal of Physiology. Endocrinology and Metabolism·Frank GonzálezJudi Minium
Sep 9, 2011·International Journal of Pediatric Endocrinology·David H GellerUNKNOWN of the Drug and Therapeutics Committee of the Pediatric Endocrine Society
Jul 17, 2012·Fertility and Sterility·Vincenzina BruniMassimiliano Fambrini
Apr 21, 2009·Metabolism: Clinical and Experimental·Frank GonzálezJohn P Kirwan
Jun 15, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Paolo Moghetti, Vincenzo Toscano
Jun 15, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Julia Warren-Ulanch, Silva Arslanian
Dec 20, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M MitkovD Terzieva
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Paula J Adams Hillard
May 3, 2007·Expert Opinion on Pharmacotherapy·Andrea J Rapkin, Sharon A Winer
Dec 9, 2017·Reproductive Biology and Endocrinology : RB&E·Sebastião Freitas de Medeiros
Sep 26, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dinka Pavicic BaldaniMiro Kasum
Mar 26, 2005·Human Reproduction Update·J Vrbíková, D Cibula
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Lourdes IbáñezFrancis de Zegher
Jun 30, 2005·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezJohn P Kirwan
Jan 13, 2006·Human Reproduction Update·Lourdes Ibáñez, Francis de Zegher
Dec 19, 2020·International Journal of Molecular Sciences·Andrea CignarellaCarla Scaroni
Mar 26, 2021·Human Reproduction Update·Sebastião Freitas de MedeirosRobert John Norman
Oct 12, 2021·American Journal of Physiology. Endocrinology and Metabolism·Frank GonzálezAnthony J Acton

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