Fluticasone furoate/vilanterol 92/22 µg once a day: a 12-month study on outcomes in mild to moderate asthma

Therapeutic Advances in Respiratory Disease
Roberto W Dal NegroPaola Turco

Abstract

Fluticasone furoate/vilanterol (FF/V) is an effective long-acting β2 agonist/inhaled corticosteroid combination for managing persistent bronchial asthma. The aim of the study was to assess the outcomes achievable in patients with mild to moderate asthma receiving FF/V 92/22 µg once daily for 12 months. Data were automatically and anonymously obtained from the institutional database: forced expiratory volume in 1 s predicted values; the exacerbation and hospitalization rates; days of hospitalization; general practitioner (GP) or specialist visits; days of inactivity; courses of systemic steroids or antibiotics were recorded at baseline and after 3, 6 and 12 months of treatment. The overall adherence to treatment was also calculated. Analysis of variance was used for checking the trends of variables. The improvement in lung function was significant ( p < 0.001) and time dependent. The mean (±standard error) exacerbation rate per patient changed from 1.05 (±0.16) at baseline to 0.28 (±0.07) after 3 months, 0.33 (±0.08) after 6 months and 0.18 (±0.08) after 12 months ( p < 0.001). The mean hospitalization rate per patient changed from 0.30 (±0.07) at baseline to 0.08 (±0.04) after 3 months, 0.10 (±0.05) after 6 months and 0.03 (±0....Continue Reading

References

Jun 19, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mark SalterDavid W Gray
Nov 8, 2012·The Journal of Pharmacology and Experimental Therapeutics·Robert J SlackRichard G Knowles
Aug 21, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·David I BernsteinPaul M O'Byrne
May 26, 2016·Expert Review of Respiratory Medicine·Emma L GrayPaul S Thomas

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