PMID: 8959118Nov 1, 1996Paper

Fluticasone propionate 1 mg daily and beclomethasone dipropionate 2 mg daily: a comparison over 1 yr

Respiratory Medicine
K A LorentzenT A Harris

Abstract

This study was designed primarily to assess the safety and tolerability of fluticasone propionate (FP) 1 mg day-1 by comparison with beclomethasone dipropionate (BDP) 2 mg day-1 over a 12-month study period. Lung function data were also recorded and used to determine whether the potency ratio between the two inhaled corticosteroids observed in previous studies was maintained in the long-term. Two hundred and thirteen patients with an established clinical history of severe chronic asthma and who were currently receiving between 1000 micrograms and 2000 micrograms day-1 of inhaled steroids were randomized to treatment in a ratio of 3:1 for FP:BDP (159 patients FP; 54 patients BDP), both via metered dose inhalers. Both treatments were well tolerated with a similar adverse event profile. No unexpected adverse events were recorded. Most adverse events were related to the patients' asthma, an intercurrent infection or underlying atopy. The incidence of pharmacologically predictable adverse events was equally low in both treatment groups as was the incidence of events suggestive of systemic steroid effect. Mean serum cortisol levels remained within the normal range at all visits for both treatments. At 12 months, however, the mean cor...Continue Reading

References

Jun 1, 1992·Thorax·D M Geddes
Nov 1, 1990·Respiratory Medicine·S M Harding
Oct 1, 1993·The American Review of Respiratory Disease·P J Barnes, S Pedersen
Oct 1, 1993·Thorax·J P Monson

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Citations

Oct 15, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Geoff K Frampton, Jonathan Shepherd
Aug 13, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Carolyn RutherfordMartin J Price
May 18, 1999·The Journal of Allergy and Clinical Immunology·G D RaphaelW R Lincourt
Feb 25, 1998·Respiratory Medicine·A P Greening
Oct 19, 2007·The Cochrane Database of Systematic Reviews·N AdamsP W Jones
Mar 17, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Anwar K Abdullah, Salman Khan

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