PMID: 9188929Apr 1, 1997Paper

Fluticasone propionate aqueous nasal spray compared with oral loratadine in patients with seasonal allergic rhinitis

Allergy
P Géhanno, J L Desfougeres

Abstract

The effectiveness and safety of fluticasone propionate aqueous nasal spray (200 micrograms once daily for 4 weeks) were compared with those of loratadine (10 mg once daily for 4 weeks) in 114 adults and adolescents with seasonal allergic rhinitis in this multicenter, double-blind, double-dummy, randomized, parallel-group study. Patients recorded their nasal symptoms (nighttime and daytime obstruction, sneezing, itching, rhinorrhea, and overall discomfort) using a 4-point scale (0 = no symptoms, 3 = very frequent symptoms) in daily diaries. Clinicians assessed patients' nasal symptoms (nighttime and daytime obstruction, sneezing, itching, and rhinorrhea) using a 4-point scale at every scheduled visit. Clinicians and patients assessed the overall effectiveness of treatment at the end of the study. Fluticasone propionate improved clinician-rated total nasal symptom scores (defined as the sum of five nasal symptoms) more than loratadine at the 2-week and 4-week assessments (P < or = 0.008). Clinicians give fluticasone propionate better global ratings than loratadine (P = 0.04). After 4 weeks of treatment, between-group differences in clinician-rated individual nasal symptoms favored fluticasone propionate (P < 0.05), with the excep...Continue Reading

References

Jan 1, 1990·Respiratory Medicine·J A Wedzicha, M C Pearson
Nov 1, 1990·Respiratory Medicine·S M Harding

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Citations

Nov 28, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Anahí Yáñez, Gustavo J Rodrigo
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G K Scadding
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Di LorenzoC Caruso
May 14, 2010·International Journal of General Medicine·Eli O MeltzerGlenis Scadding
Nov 10, 2001·PharmacoEconomics·A Tripathi, R Patterson
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P van Cauwenberge
Feb 11, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael BenningerMichael Kaliner
Jan 28, 2004·Otolaryngologic Clinics of North America·James A Hadley
Feb 25, 2017·American Journal of Rhinology & Allergy·Nanna Juel-BergMorten S Opstrup
Jul 21, 1998·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W W Storms
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Lars P Nielsen, Ronald Dahl
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W W BusseR J Horwitz
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization

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