Fluticasone propionate attenuates ozone-induced rhinitis and mucous cell metaplasia in rat nasal airway epithelium

American Journal of Respiratory Cell and Molecular Biology
J A HotchkissJack R Harkema

Abstract

Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical anti-inflammatory corticosteroid in preventing O3-induced rhinitis and mucous cell metaplasia in rat nasal epithelium. Male F344 rats were exposed to filtered air (0 ppm O3; air-controls) or 0.5 ppm O3, 8 h/day, for 3 or 5 days. Immediately before and after each exposure, rats received an intranasal instillation (50 microl/nasal passage) of a topical corticosteroid, fluticasone propionate (FP; 25 microg/nasal passage) or its vehicle only (0.01% ethanol in saline). Rats were killed 2 h after the third exposure (3-day exposure) or 3 days after the fifth exposure (5-day exposure) and nasal tissues were processed for light microscopy. Numeric densities of epithelial cells and neutrophils, and the amount of intraepithelial mucosubstances (IM) in the epithelium lining the maxilloturbinates were morphometrically determined. There were no significant differences in any measured parameter in air-exposed rats instilled with FP compared with air-exposed rats instilled with vehicle. Vehicle-treat...Continue Reading

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Citations

Jul 31, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·L NikasinovicN Seta
Jun 5, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Marisa L MeyerJudith A Voynow
Dec 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephan A CareyJack R Harkema
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·H Y ChoJ R Harkema
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Jan 24, 2009·Environmental Health Perspectives·Joe L Mauderly, Jonathan M Samet
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Jan 12, 2010·Toxicology Letters·Darrell R BoverhofMichael R Woolhiser
Aug 12, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jack R Harkema, James G Wagner
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Jul 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judith A VoynowW Michael Foster
Oct 10, 2006·Respiration; International Review of Thoracic Diseases·Barbara VagagginiPierluigi Paggiaro
Dec 24, 2005·Physiological Reviews·Mary Callaghan Rose, Judith A Voynow

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