PMID: 8947070Nov 1, 1996Paper

Fluticasone propionate compared with budesonide: a double-blind trial in asthmatic children using powder devices at a dosage of 400 microg x day(-1)

The European Respiratory Journal
J C HoekxJ Efthimiou

Abstract

The aim of this study was to compare fluticasone propionate (FP) with budesonide (BUD) at a dose of 400 microg x day(-1) in the treatment of children with asthma. Two hundred and twenty nine children with mild-to-moderate asthma, currently receiving 200-400 microg x day(-1) of inhaled corticosteroid, were randomized to receive either 400 microg x day(-1) of FP from the Diskhaler (registered trade mark of the Glaxo Group of Companies) or 400 microg x day(-1) of BUD from the Turbuhaler (registered trade mark of Astra Pharmaceuticals Ltd) for 8 weeks, in a parallel-group, double-blind, double-dummy study. Primary efficacy was assessed by measurement of daily peak expiratory flow (PEF). In addition, pulmonary function tests were performed at each clinic visit and a self-administered patient-centred questionnaire was completed by one parent of each patient at the start and end of study treatment. Mean morning PEF increased following treatment both with FP and BUD, but was significantly higher following treatment with FP during Weeks 1-4 (p=0.015) and Weeks 1-8 (p=0.019). Similar results were found for mean evening PEF and percentage predicted morning and evening PEF. Children receiving FP experienced significantly less disruption in...Continue Reading

Citations

Oct 15, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Geoff K Frampton, Jonathan Shepherd
Jul 5, 2003·Advanced Drug Delivery Reviews·P W Barry, C O'Callaghan
Apr 24, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William E Berger, Gail G Shapiro
May 22, 2003·Paediatric Respiratory Reviews·Suzanne Crowley
Mar 4, 2000·Allergy·G PassalacquaH J Malling
Nov 14, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·O D Wolthers, C Heuck
Apr 1, 1998·American Journal of Respiratory and Critical Care Medicine·P J BarnesW W Busse
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Caroline S Pao, Sheila A McKenzie
Feb 25, 2014·International Journal of Clinical Pharmacy·Lise Aagaard, Ebba Holme Hansen
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A G Staresinic, C A Sorkness
Nov 22, 2005·Expert Opinion on Drug Delivery·William E Berger
Dec 17, 2014·Evidence-based Child Health : a Cochrane Review Journal·Linjie ZhangFrancine M Ducharme
Jul 21, 1998·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W W Storms
Sep 25, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·O D Wolthers, J W Honour
Jan 30, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Carlos E Rodríguez-MartínezJose A Castro-Rodriguez
Nov 4, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·A MoriceUNKNOWN Trumpet Study Group
Jul 18, 2014·The Cochrane Database of Systematic Reviews·Linjie ZhangFrancine M Ducharme
Oct 19, 2007·The Cochrane Database of Systematic Reviews·N AdamsP W Jones
Jan 8, 2018·Indian Journal of Pediatrics·Satnam Kaur, Varinder Singh
Jun 8, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·F KarakoçE Dagli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.